Cardiovascular pathology in 2 young adults with sudden, unexpected death due to coronary aneurysms from Kawasaki disease in childhood

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Chisato ShimizuJane C Burns

Abstract

Coronary artery aneurysms (CAA) may remain silent after Kawasaki disease (KD) until adulthood when myocardial ischemia can lead to sudden death. We postulated that there would be young adults with sudden, unexpected death due to CAA from KD who would have a state-mandated autopsy performed by the San Diego County Medical Examiner's Office (SDCMEO). We reviewed all autopsy cases <35years of age from 1997 to 2012 at the SDCMEO with a cardiovascular cause of death (n=154). We found 2 cases meeting inclusion criteria. Case 1 was a 22-year-old Korean male with chronic ischemic changes due to a partially occluded and diffusely calcified 15mm aneurysm at the bifurcation of the left main coronary artery. Interview of the mother revealed that this patient had been diagnosed with KD complicated by giant aneurysms at age two years. Case 2 was a 30-year-old Hispanic male with myocardial infarction due to thrombosis of a calcified left anterior descending artery aneurysm. Histologic findings included diffuse myocardial fibrosis and a recanalized aneurysm in the right coronary artery. Interview of the family revealed a KD-compatible illness in childhood. Immunohistochemical staining showed expression of transforming growth factor β pathway m...Continue Reading

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Citations

Oct 16, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Lori B Daniels, Jane C Burns
Aug 28, 2015·International Journal of Cardiology·Fujito NumanoLori B Daniels
Apr 9, 2016·JACC. Cardiovascular Interventions·John B GordonJane C Burns
Apr 6, 2017·International Journal of Rheumatic Diseases·Rajesh VijayvergiyaSurjit Singh
Jul 29, 2017·Pediatric Research·Cassidy Y HuangChisato Shimizu
Jul 26, 2019·The Journal of International Medical Research·Xiqiang WangXiaojuan Fan
Nov 20, 2016·Journal of Forensic Sciences·Martin JaníkIvo Šteiner
Apr 7, 2020·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Katherine StaatsJ Joelle Donofrio-Odmann
Oct 20, 2020·Frontiers in Pediatrics·Rakesh Kumar PilaniaSurjit Singh
Feb 2, 2021·IJC Heart & Vasculature·Susan M DusenberyAndrew J Powell

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