Cardiovascular Patterning as Determined by Hemodynamic Forces and Blood Vessel Genetics

PloS One
Gregory A AndersonR Mark Henkelman

Abstract

Vascular patterning depends on coordinated timing of arteriovenous specification of endothelial cells and the concomitant hemodynamic forces supplied by the onset of cardiac function. Using a combination of 3D imaging by OPT and embryo registration techniques, we sought to identify structural differences between three different mouse models of cardiovascular perturbation. Endoglin mutant mice shared a high degree of similarity to Mlc2a mutant mice, which have been shown to have a primary developmental heart defect causing secondary vessel remodeling failures. Dll4 mutant mice, which have well-characterized arterial blood vessel specification defects, showed distinct differences in vascular patterning when compared to the disruptions seen in Mlc2a-/- and Eng-/- models. While Mlc2a-/- and Eng-/- embryos exhibited significantly larger atria than wild-type, Dll4-/- embryos had significantly smaller hearts than wild-type, but this quantitative volume decrease was not limited to the developing atrium. Dll4-/- embryos also had atretic dorsal aortae and smaller trunks, suggesting that the cardiac abnormalities were secondary to primary arterial blood vessel specification defects. The similarities in Eng-/- and Mlc2a-/- embryos suggest ...Continue Reading

References

Mar 15, 1994·Genes & Development·P J SwiatekT Gridley
Mar 1, 1994·Journal of Computer Assisted Tomography·D L CollinsA C Evans
Apr 10, 1999·Human Molecular Genetics·Y XueT Gridley
May 29, 1999·Science·D Y LiD P Wendel
Nov 24, 1999·The Journal of Clinical Investigation·A BourdeauM Letarte
Jul 12, 2002·Genesis : the Journal of Genetics and Development·Alexey VeraksaWilliam McGinnis
May 22, 2003·Cardiovascular Research·Mark J Solloway, Richard P Harvey
May 12, 2004·Developmental Biology·Scott R MayAndrew S Peterson
Oct 7, 2004·Genes & Development·António DuarteJanet Rossant
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nicholas W GaleGeorge D Yancopoulos
Aug 23, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·W Scott Argraves, Christopher J Drake
Sep 9, 2006·Developmental Biology·Lanying SongH Scott Baldwin
Oct 10, 2006·Neuroendocrinology·Kirti Chaturvedi, Dipak K Sarkar
Feb 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Steven SuchtingAnne Eichmann
Aug 28, 2007·Development·Jennifer L LucittiMary E Dickinson
Aug 7, 2008·PloS One·Johnathon R WallsR Mark Henkelman
Apr 9, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·James C Culver, Mary E Dickinson
May 25, 2011·The Journal of Clinical Investigation·Marie JeanssonSusan E Quaggin
Nov 15, 2011·Circulation Research·Stryder M MeadowsOndine Cleaver
Jun 22, 2012·Physiological Genomics·Jacqueline A GleaveBrian J Nieman
Aug 9, 2012·Development·Michael D WongR Mark Henkelman
Feb 19, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gregory A AndersonR Mark Henkelman
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Ryan S UdanMary E Dickinson
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Natalia SacilottoSarah De Val
Sep 12, 2013·PloS One·Michael D WongR Mark Henkelman
May 23, 2014·Development·Michael D WongR Mark Henkelman
Aug 29, 2014·Journal of the Royal Society, Interface·Madeline MidgettSandra Rugonyi

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Citations

Jul 19, 2016·Current Opinion in Pediatrics·Ellen Dees, H Scott Baldwin
Jul 18, 2018·Developmental Biology·Tanner G HoogRyan S Udan
Dec 3, 2021·Journal of Cellular and Molecular Medicine·Junming SunMin He

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