Cardiovascular performance and oxyhemoglobin dissociation after acetazolamide in metabolic alkalosis

Intensive Care Medicine
P G Berthelsen


In patients with metabolic alkalosis, compensatory alveolar hypoventilation may induce hypercapnia and hypoxemia. In edematous or normally-hydrated patients without electrolyte deficiencies, acetazolamide--a carbonic anhydrase inhibitor--has been advocated to correct the primary acid-base disturbance, thereby preventing hypoxemia. The hemodynamic consequences and the effect on oxyhemoglobin dissociation of acetazolamide, were studied. Twelve critically ill patients with metabolic alkalosis were given 15 mg/kg body wt. acetazolamide intravenously. Cardiovascular performance was completely unchanged. The P50 was 26.6 mm Hg at the beginning and the end of the study, indicating that hemoglobin-oxygen affinity is unaffected by acetazolamide. In six patients, investigated after open-heart surgery, the arterial oxygen tension increased by 10-45%. This was probably related to the combined effects of slight reductions in total body oxygen consumption or shunting of venous blood through the lungs. Eight of the 12 patients were on controlled ventilation. After acetazolamide there was a mean increase in mixed venous carbon dioxide tension (PvCO2) of 4.5 mm Hg, with no increase in arterial carbon dioxide tension (PaCO2), indicating only a l...Continue Reading


Jan 10, 2004·The Journal of Laboratory and Clinical Medicine·Xuefeng GaiHisayo Nagaishi
Aug 8, 2012·Critical Care : the Official Journal of the Critical Care Forum·Nicholas HemingChristophe Faisy
Jan 20, 2006·Critical Care : the Official Journal of the Critical Care Forum·Miriam MoviatJohannes G van der Hoeven
Dec 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tze-Kai WangMingli Hsieh
Mar 1, 1992·The Journal of Pediatrics·D A BenaronP A Dennery
Mar 27, 2015·International Journal of Critical Illness and Injury Science·Mabrouk BahloulMounir Bouaziz
Jan 24, 2018·The Annals of Pharmacotherapy·Jason D GuffeyDavid C Kaufman
Jun 4, 2019·Journal of Neuroscience Research·Mingli HsiehChe-Min Lo
Jan 1, 1987·Intensive Care Medicine·P G Berthelsen, J O Dich-Nielsen


Jan 1, 1976·British Journal of Haematology·M A LichtmanM Pogal
Jul 1, 1979·Southern Medical Journal·T J Gallagher
Dec 13, 1979·The New England Journal of Medicine·J R SuttonA C Powles
Nov 28, 1977·JAMA : the Journal of the American Medical Association·P D Miller, A S Berns
Aug 1, 1977·British Journal of Anaesthesia·L I Worthley
Mar 18, 1972·Lancet·M H TattersallA S Spiers
Sep 19, 1968·The New England Journal of Medicine·W B SchwartzJ P Kassirer
Feb 1, 1972·Chest·T M JarboeR G Luke
Aug 1, 1972·Archives of Surgery·R F WilsonC Lucas
Nov 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·G Rooth, L Jacobson
Mar 1, 1971·The American Journal of Medicine·M A Tuller, F Mehdi
Dec 1, 1980·Critical Care Medicine·J E HodgkinD M Chan
Nov 1, 1961·Journal of Applied Physiology·S M CAIN, A B OTIS
Jan 1, 1968·The Journal of Clinical Investigation·R M GoldringA P Fishman

Related Concepts

Acetazolamide Sodium, (Sterile)
Cardiovascular Diseases
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Carbon Dioxide
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