Cardiovascular pressor effects of orexins in the dorsomedial hypothalamus

European Journal of Pharmacology
Tzu-Ling LiLing-Ling Hwang

Abstract

Orexins are important regulators of cardiovascular functions in various physiological and pathological conditions. The dorsomedial hypothalamus (DMH), an essential mediator of cardiovascular responses to stress, contains dense orexinergic innervations and receptors. We examined whether orexins can regulate cardiovascular functions through their actions in the DMH in anesthetized rats. An intra-DMH injection of orexin A (30pmol) produced elevation of arterial pressure and heart rate. Orexin A-sensitive sites were located within or immediately adjacent to the DMH and larger responses were induced at the compact part of the dorsomedial hypothalamic nucleus. Orexin A-induced responses were attenuated by intra-DMH pretreatment with an orexin receptor 1 (OX1R) antagonist, SB-334867 (15nmol) (17.7 ± 2.8 vs. 5.2 ± 1.0mmHg; 54.6 ± 10.0 vs. 22.8 ± 7.4 beats/min). Intra-DMH applied [Ala11,D-Leu15]-orexin B (300 pmol), an orexin receptor 2 (OX2R) agonist, elicited cardiovascular responses mimicking the responses of orexin A, except for a smaller pressor response (7.4 ± 1.7 vs. 16.4 ± 1.8mmHg). In a series of experiment, effects of orexin B (100pmol) and then orexin A (30pmol), were examined at a same site. Two patterns of responses were ob...Continue Reading

Citations

Jul 13, 2018·IUBMB Life·Xuesong HanWei Peng
Jul 12, 2018·Current Hypertension Reports·Mariusz SieminskiEemil Partinen
Feb 15, 2021·Sleep Medicine Reviews·Poul Jørgen JennumYves Dauvilliers
Oct 18, 2021·The FEBS Journal·Qingqing Lu, Jin Young Kim

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