Cardiovascular Protection of Nephropathic Male Patients by Oral Food Supplements

Cardiovascular Therapeutics
Annalisa NoceAnnalisa Romani

Abstract

Nephropathic patients show elevated cardiovascular morbidity and mortality compared to the general population. In order to delve deeper into the understanding of this phenomenon, it is necessary to recognize risk factors that are distinctive to the uremic state, such as oxidative stress and chronic low-grade inflammation. Moreover, gender differences have been reported in nephrology, as it has been observed that chronic kidney disease has higher prevalence in males than in females. The use of an oral food supplement (OFS) containing natural active compounds from Capsicum annuum L., Garcinia cambogia, Centella asiatica L., artichoke, and Aesculus hippocastanum L. which are virtually devoid from side effects, but rich in antioxidant and antiradical properties, could represent a valid therapeutic adjunct in the clinical management of nephropathic patients. Moreover, quantitative analysis performed in vitro on such compounds showed that they expressed good total antioxidant (7.28 gallic acid equivalents) and antiradical activity (above 80%). In this study, 23 male nephropathic patients and 10 age and body composition parameter matched healthy males (control group) were enrolled and took 3 cps/day of OFS for 5 weeks. At the end of t...Continue Reading

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Citations

Oct 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annalisa RomaniNicola Di Daniele
Jan 8, 2021·Nutrients·Annalisa NoceNicola Di Daniele
Mar 7, 2021·Nutrients·Annalisa NoceNicola Di Daniele
Apr 4, 2021·Nutrients·Giulia MarroneAnnalisa Noce

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Methods Mentioned

BETA
ESR

Software Mentioned

GraphPad Prism
Statistical Package for the Social Sciences

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