PMID: 2383216May 1, 1990Paper

Cardiovascular reactions and respiratory events during platelet activating factor-induced shock

Basic Research in Cardiology
S B FelixW E Berdel

Abstract

The platelet activating factor (PAF), a low molecular phospholipid, plays an important role in inflammation, anaphylaxis, and shock state development. In the isolated perfused guinea pig heart, PAF induces a decrease in coronary flow and cardiac contractility and atrioventricular conduction disturbances. Furthermore, PAF mediates a powerful bronchoconstrictory action causing a severe impairment in respiratory function. In the present study an attempt was made to separate cardiac from respiratory events during PAF-induced shock in vivo. PAF was injected intravenously (0.1-10 micrograms/kg) into anesthetized guinea pigs ventilated with room air or 100% oxygen. Administration of 10 micrograms/kg PAF was uniformly lethal: already within 2 min, cardiac output decreased by 60% and end-diastolic left ventricular pressure increased markedly indicating cardiac failure. ECG recordings showed signs of acute myocardial ischemia. Arrhythmias occurred in terms of atrioventricular conduction delay. Blood pressure initially increased, then declined continuously to below baseline within 10 min. All animals died within 25 min. Ventilation with room air was paralleled by development of severe hypoxia. However, under ventilation with 100% oxygen a...Continue Reading

References

Jun 28, 1979·Nature·M ChignardJ Benveniste
Oct 29, 1979·Biochemical and Biophysical Research Communications·M L BlankE E Muirhead
Apr 1, 1987·British Medical Bulletin·B B Vargaftig, P G Braquet
Aug 1, 1987·Prostaglandins·P Braquet, M Rola-Pleszczynski
Oct 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·G L StahlA M Lefer
Aug 1, 1986·Pharmacological Research Communications·M Sanchez CrespoS Fernandez-Gallardo
Feb 26, 1985·European Journal of Pharmacology·Z TerashitaS Sumida
Sep 1, 1984·British Journal of Pharmacology·A M LeferJ B Smith
Dec 9, 1983·European Journal of Pharmacology·J Björk, G Smedegård
Jan 21, 1983·European Journal of Pharmacology·P BessinJ Benveniste
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·G NeumannG Blümel

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Citations

Feb 1, 1994·Clinical and Experimental Pharmacology & Physiology·K E AndersonE A Woodcock
Jan 1, 1996·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E V TibiriçáR S Cordeiro
Mar 24, 2000·The Journal of Surgical Research·W Z WangF N Miller

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