Abstract
Studies have shown that the angiotensin II AT(1) receptor antagonist, losartan, accentuates the hypotensive response in the orthostatic stress test (tilt) performed in anaesthetized rats. The same effect was not reported with other AT(1) antagonists. The aim of this study was to re-evaluate the effects of AT(1) receptor blockade on the cardiovascular response to tilt in a model developed for conscious rats. Rats (n=5-7 per group) were instrumented for infusion of drugs and recording of cardiovascular parameters and, after recovery, placed in a plastic tube positioned over the tilt board. The tilt test was conducted by raising the head side of the tilt board from horizontal position to 75 degrees head up position for 15 min. Compared with control group (NaCl 0.9%, 1 ml kg(-1)), oral treatment with 1 mg kg(-1) per day of losartan or telmisartan did not alter the blood pressure response during tilt. With the 10 mg kg(-1) dose, both antagonists altered the blood pressure response during tilt (mean maximum changes -11+/-3 mm Hg; P<0.01). A post-tilt hypotension was observed with both doses in losartan and telmisartan groups (-13+/-1 and -9+/-2 mm Hg, respectively; P<0.01). The present results indicate that the effect of losartan on ...Continue Reading
References
Feb 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·M J Fregly, N E Rowland
May 1, 1991·Anesthesia and Analgesia·J V Mirenda, T E Grissom
Jan 1, 1982·Journal of Pharmacological Methods·S J Humphrey, R B McCall
Jan 1, 1993·Brain Research Bulletin·Z LiA V Ferguson
May 1, 1996·Drugs·K L Goa, A J Wagstaff
Nov 1, 1996·American Journal of Hypertension·H Rieckert
Mar 7, 1997·Brain Research·M A FontesR A Santos
Oct 6, 1998·Journal of the Autonomic Nervous System·A ShimokawaH Kannan
Nov 30, 1999·Anesthesia and Analgesia·P ColsonP Coriat
Dec 2, 1999·Japanese Journal of Pharmacology·Y HashimotoH Narita
May 10, 2000·Drugs & Aging·K L Simpson, K J McClellan
Oct 4, 2000·Physiological Genomics·M A FontesR A Santos
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·R A L DampneyT Tagawa
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Marc P MaillardMichel Burnier
Nov 6, 2002·Annals of Internal Medicine·David S GoldsteinGraeme Eisenhofer
Mar 1, 2003·Acta Physiologica Scandinavica·R A L DampneyJ W Polson
Feb 3, 2005·British Journal of Pharmacology·Marina Matos de MouraMarco Antônio Peliky Fontes
Oct 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mohammed J SheriffRoger A L Dampney
Jan 10, 2006·Drugs·Anna J Battershill, Lesley J Scott
Nov 4, 2006·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Carlos M Ferrario
Citations
Mar 15, 2016·Frontiers in Cardiovascular Medicine·Theo Walther Jensen, Niels Vidiendal Olsen
Jun 10, 2016·Journal of Cardiovascular Pharmacology and Therapeutics·Matthew AmoniAsfree Gwanyanya
Aug 2, 2011·Cardiovascular Toxicology·Sandra PicardRené Rouet
Mar 7, 2015·Life Sciences·A S SilvaM C Martins-Pinge