PMID: 6107093Sep 1, 1980Paper

Cardiovascular reflexes in patients after myocardial infarction. Effect of long-term treatment with beta-adrenoceptor antagonists

British Heart Journal
T BennettJ R Hampton

Abstract

A double-blind study was made of men who had had a myocardial infarction at least one year previously, and who were being treated with propranolol, atenolol, or placebo. They were compared with age- and sex-matched control subjects. Under resting conditions, there were no differences between the systemic arterial blood pressures, forearm blood flows, or heart rates of the control subjects and the post-infarction patients treated with placebo. The patients, however, showed signs of reduced sympathetic effects on the cardiovascular system when their reflex responses to the Valsalva manoeuvre, lower body negative pressure, and performance of a mental task were assessed. Long-term treatment with propranolol or artenolol had little effect on resting systemic arterial blood pressure or forearm blood flow, but caused a significant reduction in resting heart rate. Differences in the reflex responses of these patients and those on placebo were attributable to the effects of the beta-adrenoceptor antagonists on resting heart rate. These results indicate that post-infarction patients do not have signs of overactivity of autonomic nervous control of the cardiovascular system. Furthermore, long-term treatment of such patients with beta-adre...Continue Reading

References

Mar 22, 1976·European Journal of Clinical Pharmacology·L HanssonB E Karlberg
Feb 1, 1977·British Heart Journal·B J Kirby
Jan 1, 1976·Australian and New Zealand Journal of Medicine·J BrodO Rienhoff
Feb 1, 1976·Journal of Neurology, Neurosurgery, and Psychiatry·T BennettJ R Hampton
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Citations

Nov 15, 1989·Journal of the American College of Cardiology·J T BiggerP J Schwartz
Feb 11, 1991·Journal of the American College of Cardiology·J R CookL M Rolnitzky
Sep 1, 1988·Journal of the American College of Cardiology·P J SchwartzA Zanchetti
Apr 1, 1996·Pacing and Clinical Electrophysiology : PACE·A J BurgerR Nesto
Dec 1, 1987·British Heart Journal·K E AiraksinenJ T Takkunen
Aug 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·M S DetollenaereD L Clement
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·M A van BaakJ F Smits
Sep 1, 1991·The American Journal of Cardiology·R E KleigerJ L Fleiss
Sep 1, 1989·International Journal of Cardiology·M J NiemeläJ T Takkunen
Jun 1, 1987·Research in Nursing & Health·J Herman
Feb 1, 1988·The American Journal of Cardiology·J T BiggerJ P Miller

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