Cardiovascular reflexes stimulated by reperfusion of ischemic myocardium in acute myocardial infarction

Circulation
J Y WeiE Braunwald

Abstract

Acute myocardial infarction (AMI), especially of the inferior left ventricular wall, where most cardiac receptors with vagal afferents that are stimulated during coronary occlusion are located, is commonly associated with reflex hypotension and sinus bradycardia. To determine whether reperfusion of an acutely ischemic area can activate cardiac reflexes, changes in the heart rate, arterial pressure and rhythm were correlated with the time course and location of intracoronary thrombolytic therapy in 41 patients with AMI. Of the 27 patients with successful reperfusion, 17 developed significant transient bradycardia and hypotension and one became tachycardic and hypertensive at the time of recanalization. Spontaneous reversion of the bradycardia and hypotension occurred definitely in six patients and possibly in more (nine reverted after atropine and two after fluids). A positive correlation existed between the changes in heart rate and blood pressure, in contrast to the usual inverse relationship when baroreceptors are stimulated. Two of the three patients in whom reperfusion was transient also developed hypotension and bradycardia. In contrast, all 11 patients with persistent occlusion demonstrated no reflex cardiovascular change...Continue Reading

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J A EstrinI J Fox
Jul 1, 1979·British Heart Journal·F Perez-GomezA Garcia Aguado
Sep 1, 1977·British Heart Journal·F Perez-Gomez, A Garcia-Aguado
Jul 8, 1972·British Medical Journal·S W WebbJ F Pantridge
Dec 1, 1974·The Journal of Clinical Investigation·D L EckbergF M Abboud
Jul 1, 1974·The American Journal of Physiology·A L MarkU J Johannsen
Nov 1, 1971·The American Journal of Physiology·R J Frink, T N James
Jan 1, 1981·American Heart Journal·W GanzH J Swan
Mar 1, 1981·Clinical Cardiology·R M Robertson, D Robertson
Oct 1, 1981·The New England Journal of Medicine·J E MarkisE Braunwald
Oct 16, 1980·The New England Journal of Medicine·M A DeWoodH T Lang
Oct 1, 1955·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·A S PAINTAL
Feb 1, 1963·The American Journal of Cardiology·L COSTANTIN
Mar 1, 1965·The Journal of Physiology·A M BROWN

❮ Previous
Next ❯

Citations

Jul 14, 2000·Clinical Cardiology·S A Haji, A Movahed
Feb 14, 2009·Herzschrittmachertherapie & Elektrophysiologie·Ali ErdoganNedim Soydan
Oct 1, 1993·Journal of the American College of Cardiology·J S Floras
Jan 1, 1993·Journal of the American College of Cardiology·P K ShahW Ganz
Aug 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rajesh VenkataramanAmi E Iskandrian
Feb 5, 1998·Progress in Cardiovascular Diseases·J A Goldstein
Apr 14, 1997·Journal of the Autonomic Nervous System·S S MeyrellesE C Vasquez
Sep 13, 2002·Journal of the American College of Cardiology·James A Goldstein
Jun 1, 1985·Journal of the American College of Cardiology·D RobertsonR M Robertson
Sep 20, 1984·The New England Journal of Medicine·G L Laffel, E Braunwald
Aug 1, 1996·Clinical and Experimental Pharmacology & Physiology·H D Schultz, E E Ustinova
Aug 1, 1996·Clinical and Experimental Pharmacology & Physiology·M D ThamesT Kinugawa
Dec 10, 1990·Journal of Interventional Cardiology·D E SpanglerJ Corrao
Aug 18, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Zhi-Ling GuoJohn C Longhurst
Oct 24, 2012·Current Problems in Cardiology·James A Goldstein
May 3, 2012·Cardiology Clinics·James A Goldstein
Dec 30, 2006·Medicina intensiva·M Ruiz-BailénUNKNOWN Grupo ARIAM
Aug 31, 2006·Cardiology Clinics·Shaul AtarYochai Birnbaum
Jan 15, 2009·Pacing and Clinical Electrophysiology : PACE·Tatsuya KawasakiHiroki Sugihara
Jul 1, 1988·The American Journal of Cardiology·J Y Wei
Mar 1, 1993·The American Journal of Emergency Medicine·R B Vukmir
Aug 1, 1983·The American Journal of Cardiology·P EsenteC Dator
Sep 1, 1988·International Journal of Cardiology·M C SolimeneF Pileggi
Apr 1, 1984·International Journal of Cardiology·J Y WeiE Braunwald
Aug 1, 1994·International Journal of Cardiology·Y BirnbaumB Stahl
Oct 1, 1986·American Heart Journal·C K HuangM M Mower
Oct 4, 2005·Emergency Medicine Clinics of North America·Andrew D Perron, Timothy Sweeney
Sep 18, 1998·Emergency Medicine Clinics of North America·T P Aufderheide
Apr 12, 2000·The American Journal of Cardiology·H BonnemeierG Richardt
Sep 1, 1991·The Annals of Thoracic Surgery·D A FullertonW M See

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