Cardiovascular responses and neurotransmitter changes during blockade of angiotensin II receptors within the ventrolateral medulla

Neuroscience Research
Dipan PatelA Ally

Abstract

Angiotensin II (Ang II) receptors are located in different regions of the brain, particularly within the cardiovascular control centers in the brainstem. These Ang II receptors are divided into AT1 and AT2 subtypes. We investigated the role of AT1 receptor subtype within the rostral (RVLM) and caudal (CVLM) ventrolateral medulla on cardiovascular responses and glutamate/GABA neurotransmission during static exercise using microdialysis in anesthetized rats. Bilateral microdialysis of a selective AT1 receptor antagonist, ZD7155 (10 microM), for 30 min into the RVLM attenuated increases in mean arterial pressure (MAP) and heart rate (HR) during a static muscle contraction. Glutamate concentrations within the RVLM decreased while GABA levels increased simultaneously during the contraction period when compared to those before ZD7155. After 60 min of discontinuation of ZD7155, MAP, HR, glutamate, and GABA levels in response to another muscle contraction returned to baseline levels. Conversely, bilateral microdialysis of ZD7155 into the CVLM potentiated cardiovascular responses during a static muscle contraction; glutamate concentrations increased while GABA levels within the CVLM decreased. All responses recovered after 60 min of dis...Continue Reading

References

Jan 1, 1995·Clinical and Experimental Hypertension : CHE·I J Llewellyn-SmithJ P Chalmers
Jan 27, 1998·Brain Research Bulletin·D N ZhuT Ogihara
Apr 4, 1998·Pflügers Archiv : European journal of physiology·D CaringiA Ally
Mar 1, 2003·Acta Physiologica Scandinavica·R A L DampneyJ W Polson
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robson A S SantosThomas Walther
Apr 5, 2005·Brain Research·Lenice K BeckerMaria José Campagnole-Santos
Aug 23, 2006·Clinical and Experimental Pharmacology & Physiology·R H Fagard
Nov 4, 2006·Expert Review of Cardiovascular Therapy·Matthias GoebelThomas Unger

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Citations

Dec 15, 2010·Clinical and Experimental Pharmacology & Physiology·Dmitry N Mayorov
Nov 16, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Vineet C Chitravanshi, Hreday N Sapru
Dec 28, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hideki ArakawaHreday N Sapru
Jun 27, 2020·Nitric Oxide : Biology and Chemistry·Ahmmed AllySurya M Nauli

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