Cardiovascular responses of goat fetuses to hypercapnia during extrauterine incubation using extracorporeal membrane oxygenation

Fetal Diagnosis and Therapy
S ItohY Kuwabara

Abstract

The purpose of this study was to assess the effects of changes in fetal PaCO2 on circulatory functions without maternal influences. In 5 goat fetuses that were incubated using an extrauterine incubation system with arteriovenous extracorporeal membrane oxygenation, fetal carotid arterial blood flow, heart rate, mean blood pressure, and serum catecholamine levels were determined under the conditions of several grades of hypercapnia without hypoxemia. The hypercapnia was induced gradually by decreasing the flow of gas to the membrane oxygenator located on the extracorporeal circulation system. Fetal arterial CO2 tension increased significantly, from 36.2 +/- 1.1 mm Hg (means +/- SE) to 82.9 +/- 6.5 mm Hg, and the pH decreased significantly, from 7.410 +/- 0.012 to 7.121 +/- 0.028, due to the hypercapnia. In all cases, the fetal carotid arterial blood flow increased significantly (from 42.2 +/- 6.2 to 52.4 +/- 6.2 ml/min). Although a slight increase was observed in the heart rate at the mild hypercapnia stage, severe hypercapnia induced bradycardia in all cases. The mean arterial pressure and rate of extracorporeal circulation were unchanged during hypercapnia. We found that cerebral blood flow increased due to hypercapnia's direc...Continue Reading

Citations

May 21, 2003·The Journal of Obstetrics and Gynaecology Research·Nobuko NishiokaYoshiro Ehara

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