Cardiovascular responses to exercise and muscle metaboreflex activation during the recovery from pacing-induced heart failure

Journal of Applied Physiology
R A AugustyniakDonal S O'Leary

Abstract

Rapid recovery of resting hemodynamics from tachycardia- or arrhythmia-induced heart failure (HF) has been demonstrated in both humans and animals. However, little is known about cardiovascular responses to exercise in animals or about reflex control of the cardiovascular system during exercise while recovering from HF. Inasmuch as the reduced cardiac output (CO) during exercise in HF has been shown to lead to underperfusion of active skeletal muscle and tonic activation of the muscle metaboreflex, an improved CO during exercise in subjects recovering from HF may lead to higher skeletal muscle blood flows and to relief of this metabolic stimulus. We investigated cardiovascular responses to graded treadmill exercise and metaboreflex activation [evoked by imposed graded reductions in hindlimb blood flow (HLBF) during mild and moderate exercise] in chronically instrumented dogs during control, mild to moderate HF (induced by rapid ventricular pacing), and recovery from HF. Most hemodynamic responses to graded exercise returned to control within 24 h of disconnecting the pacemaker. After 2 wk of recovery, CO and HLBF at each workload were significantly higher than control. In addition, whereas the increase in CO that normally occur...Continue Reading

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Citations

Nov 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Masashi J IchinoseDonal S O'Leary
Nov 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·David C PooleTimothy I Musch
Feb 22, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marty D SprangerDonal S O'Leary
Mar 2, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Donal S O'LearyRobert A Augustyniak
Jan 9, 2007·Journal of Applied Physiology·Massimo F Piepoli, Andrew J S Coats
Jan 30, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marty D SprangerDonal S O'Leary
Nov 9, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Michelle Cristina-OliveiraTiago Peçanha
Jun 20, 2006·Journal of Applied Physiology·Michael J Joyner
Sep 25, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Jasdeep KaurDonal S O'Leary
Apr 30, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph MannozziDonal S O'Leary

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