Cardiovascular responses to microinjection of ATP into the nucleus tractus solitarii of awake rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Patrícia M De PaulaB H Machado

Abstract

Microinjection of increasing doses of ATP (0.31, 0.62, 1.25, and 2.5 nmol/50 nl) into the nucleus tractus solitarii (NTS) produced a dose-dependent pressor response. Prazosin abolished the pressor response and produced no change in the bradycardic response to ATP. Microinjection of pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid (0.25 nmol/50 nl), a nonselective P2 receptor antagonist into the NTS, reduced the bradycardic response but had no effect on the pressor response to microinjection of ATP (1.25 nmol/50 nl) into the NTS. Microinjection of suramin (2 nmol/50 nl), another nonselective P2 receptor antagonist, had no effect on the pressor and bradycardic responses to microinjection of ATP (1.25 nmol/50 nl) into the NTS. Antagonism of A1 receptors of adenosine with 1,3-dipropyl-8-cyclopentylxanthine also produced no changes in the cardiovascular responses to microinjection of ATP into the NTS. The involvement of excitatory amino acid (EAA) receptors in the pressor and bradycardic responses to microinjection of ATP into the NTS was also evaluated. Microinjection of kynurenic acid, a nonselective EAA receptor antagonist (10 nmol/50 nl), into the NTS reduced the bradycardic response and had no effect on the pressor respons...Continue Reading

References

Dec 12, 1989·European Journal of Pharmacology·R Mosqueda-GarciaD Robertson
Jan 1, 1986·Progress in Brain Research·G Burnstock
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Jan 1, 1996·Progress in Neurobiology·A J Lawrence, B Jarrott
Jan 1, 1997·The American Journal of Physiology·J H St LambertK M Spyer
Mar 1, 1997·Trends in Pharmacological Sciences·B B FredholmM Williams
Jun 1, 1997·Current Opinion in Neurobiology·R A North, E A Barnard
Oct 7, 1997·Clinical and Experimental Pharmacology & Physiology·J W PhillisD S O'Leary
Aug 29, 1998·Neuroreport·I J Llewellyn-Smith, G Burnstock
Dec 9, 1998·The American Journal of Physiology·T J Scislo, D S O'Leary
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T J Scislo, D S O'Leary
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P M de Paula, B H Machado
Apr 19, 2002·Journal of Applied Physiology·Gareth B MilesGregory D Funk
Mar 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eiji Shigetomi, Fusao Kato

❮ Previous
Next ❯

Citations

Dec 5, 2013·Physiological Reports·Daniela Accorsi-MendonçaBenedito H Machado
Apr 11, 2009·Trends in Neurosciences·Alexander V GourineGeoffrey Burnstock
Oct 22, 2008·Experimental Physiology·Daniela Accorsi-MendonçaBenedito H Machado
Apr 15, 2005·Neurological Research·Tadeusz J Scislo, Donal S O'Leary
Feb 17, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D R G de FariaP M de Paula
Sep 1, 2009·Autonomic Neuroscience : Basic & Clinical·Erica M GranjeiroBenedito H Machado
Mar 2, 2010·Autonomic Neuroscience : Basic & Clinical·Waldyr M OlivaBenedito H Machado

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.