Cardiovascular responses to open-field stress in rats: sex differences and effects of gonadal hormones

Stress : the International Journal on the Biology of Stress
N Eikelis, M van den Buuse

Abstract

We studied sex differences in cardiovascular responses to stress using a new radio-telemetry model in which freely-moving Spontaneously Hypertensive rats (SHR) are exposed to open-field novelty stress. This model allowed simultaneous assessment of cardiovascular and behavioural responses to psychological stress. Female SHR in the diestrous stage of their estrous cycle had markedly greater pressor and tachycardic responses to open-field exposure when compared to either female rats not in diestrous or male SHR. Treatment of ovariectomized SHR with estrogen alone had no significant effect on cardiovascular reactivity, while a combined treatment of estrogen and progesterone slightly, but significantly attenuated their pressor response to open-field stress. In addition, treatment of castrated male rats with testosterone significantly enhanced their pressor responses to stress when compared to values obtained before treatment. None of the hormone treatments had any significant effect on heart rate responses to stress. Neither at different stages of the estrous cycle nor after hormone treatments were there any marked changes in behavioural responses in the open-field, making it unlikely that the differences in cardiovascular stress re...Continue Reading

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Citations

Oct 24, 2001·European Journal of Pharmacology·M Van den Buuse, N Eikelis
Sep 15, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzette M Evans, Richard W Foltin
May 6, 2009·Clinical and Experimental Pharmacology & Physiology·Mahmoud M El-Mas, Abdel A Abdel-Rahman
Jul 23, 2013·PloS One·Angela KuhlaAndreas Wree
Jun 26, 2012·Behavioural Brain Research·Carsten HolzmannAndreas Wree
Dec 7, 2007·Physiology & Behavior·David J BucciJoel T Nigg
Sep 24, 2004·International Journal of Experimental Pathology·Wellington V SantosCarlos A Mandarim-de-Lacerda
Jan 6, 2009·Annals of the New York Academy of Sciences·Keiko MorimotoKen-ichi Yoshida
Aug 28, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Tim KarlStephan von Hörsten
Nov 12, 2016·International Journal of Molecular Sciences·Victoria SchlegelAndreas Wree
Nov 3, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shoko TazumiKeiko Morimoto
Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Keiko MorimotoKen-Ichi Yoshida

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