Cardiovascular responses to stress after carotid baroreceptor denervation in humans

Annals of the New York Academy of Sciences
Henri J L M TimmersJacques W M Lenders

Abstract

Iatrogenic bilateral denervation of carotid sinus baroreceptors may occur as a complication of carotid body tumor resection and radiation therapy of the neck. The acute phase of the resulting syndrome of baroreflex failure is characterized by a limited blood pressure buffering capacity against excessive rise or fall in response to emotional and physical stimuli like sexual arousal and cold. Paroxysms of severe hypertension and tachycardia, accompanied by excessive increments in sympathetic tone and catecholamine plasma levels, were ascribed to loss of tonic inhibitory influence of baroreceptors on sympathetic tone. Bilateral anesthetic blockade of baroreceptor afferent nerves was shown to result in a strong increase in muscle sympathetic nerve activity and disruption of its normal patterning. This chapter reviews our findings on the long-term effects of iatrogenic baroreflex trauma on the hemodynamic responses to pharmacological, physical, and emotional stress in the autonomic function laboratory as well as under daily life conditions. Chronic attenuation of baroreflex sensitivity after carotid body tumor resection and neck irradiation results in an increased blood pressure variability. However, unopposed sympathetic activation...Continue Reading

References

Jul 21, 1975·Pflügers Archiv : European journal of physiology·B G WallinW Delius
Jan 1, 1988·Annual Review of Physiology·B G Wallin, J Fagius
Jun 1, 1985·Brain : a Journal of Neurology·J FagiusS Englesson
Jan 1, 1974·Circulation Research·J E Angell-James
Aug 1, 1982·Circulation·D S GoldsteinH R Keiser
Mar 1, 1995·Stroke; a Journal of Cerebral Circulation·O IlleM Haguenau
Nov 11, 1993·The New England Journal of Medicine·D RobertsonR M Robertson
Jan 1, 1996·Physiological Reviews·P B Persson
Jan 13, 1998·The Journal of Laryngology and Otology·N ZidarE Soba
Jan 19, 2000·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·H J TimmersW Wieling
Sep 15, 2001·Otolaryngologic Clinics of North America·A G van der MeyJ M van Baalen
Mar 20, 2002·Circulation·Arthur A J SmitJohn M Karemaker
Mar 18, 2003·Journal of Hypertension·Henri J L M TimmersJacques W M Lenders
Jun 18, 2003·Hypertension·Henri J L M TimmersJacques W M Lenders

❮ Previous
Next ❯

Citations

Sep 10, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James P FisherPaul J Fadel
Jul 25, 2013·Journal of Community Hospital Internal Medicine Perspectives·Thein AungMahesh Krishnamurthy
Sep 29, 2011·European Journal of Applied Physiology·Xiaorui Tang, Tian Hu
May 30, 2006·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Tulio Diaz, J Andrew Taylor
May 19, 2012·Journal of Science and Medicine in Sport·Kassia S WestonJeff S Coombes
Oct 18, 2011·Experimental Physiology·Paul J Fadel, Peter B Raven
Jan 25, 2012·Pacing and Clinical Electrophysiology : PACE·Andreas VossHans R Figulla
Mar 28, 2013·American Journal of Medical Genetics. Part a·Sarah L SawyerFrancois P Bernier
Nov 12, 2015·BioMed Research International·Antonio CrisafulliShigehiko Ogoh
Nov 15, 2005·Experimental Physiology·Michael J Joyner
Nov 29, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Hanan M El-Gowelli, Mahmoud M El-Mas
Jun 16, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuki ShiinaAkira Yamashina
Jan 10, 2006·American Journal of Surgery·Theron T KnightDaniel S Rush
Aug 26, 2006·Nature Clinical Practice. Nephrology·Joshua Fessel, David Robertson
Sep 10, 2020·Seminars in Neurology·Lucy Norcliffe-KaufmannHoracio Kaufmann
Aug 28, 2020·Frontiers in Pediatrics·Yang HuJunbao Du

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The British Journal of Surgery
J T PlukkerJ J van den Dungen
Archives of Surgery
G B BishopW A Maddox
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
S J WangT C Calcaterra
© 2022 Meta ULC. All rights reserved