Cardiovascular risk assessment beyond Systemic Coronary Risk Estimation: a role for organ damage markers

Journal of Hypertension
Massimo VolpeGiuseppe Mancia

Abstract

Cardiovascular risk assessment in the clinical practice is mostly based on risk charts, such as Framingham risk score and Systemic Coronary Risk Estimation (SCORE). These enable clinicians to estimate the impact of cardiovascular risk factors and assess individual cardiovascular risk profile. Risk charts, however, do not take into account subclinical organ damage, which exerts independent influence on risk and may amplify the estimated risk profile. Inclusion of organ damage markers in the assessment may thus contribute to improve this process. Our aim was to evaluate the influence of implementation of SCORE charts with widely available indexes of organ damage, with the purpose to ameliorate individual risk assessment. We searched www.Pubmed.gov for evidence about the predictive value of left ventricular hypertrophy (LVH), estimated glomerular filtration rate (eGFR), microalbuminuria (MAU) and metabolic syndrome on different risk profiles estimated by SCORE. Interventional and observational trials including at least 200 patients and published after 2000 were selected. The presence of organ damage as well as the number of abnormal parameters indicating organ damage is associated with increased cardiovascular risk, independently ...Continue Reading

References

Jun 1, 1985·Journal of the American College of Cardiology·W B Kannel, A Schatzkin
Sep 28, 1996·BMJ : British Medical Journal·P RossingH H Parving
Feb 14, 1998·Journal of the American College of Cardiology·P VerdecchiaC Porcellati
Apr 25, 2000·Hypertension·J S JensenK Borch-Johnsen
Jul 31, 2001·JAMA : the Journal of the American Medical Association·H C GersteinUNKNOWN HOPE Study Investigators
Dec 12, 2001·Journal of the American College of Cardiology·P VerdecchiaUNKNOWN MAVI (MAssa Ventricolare sinistra nell'Ipertensione) Study Group
Sep 18, 2002·Kidney International·Ronald M A HenryCoen D A Stehouwer
Oct 3, 2002·Circulation·Hans L HillegeUNKNOWN Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group
Dec 4, 2002·JAMA : the Journal of the American Medical Association·Hanna-Maaria LakkaJukka T Salonen
Feb 7, 2003·Journal of the American College of Cardiology·Guruprasad ManjunathMark J Sarnak
Mar 13, 2003·Kidney International·Guruprasad ManjunathMark J Sarnak
Jun 6, 2003·European Heart Journal·R M ConroyUNKNOWN SCORE project group
Nov 8, 2003·Hypertension·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Apr 22, 2004·Journal of the American Society of Nephrology : JASN·Daniel E WeinerMark J Sarnak
May 18, 2004·Journal of the American College of Cardiology·Giuseppe SchillaciElmo Mannarino
May 22, 2004·Journal of the American Society of Nephrology : JASN·Julián SeguraLuis M Ruilope
Sep 15, 2004·PharmacoEconomics·Luca Degli Esposti, Giorgia Valpiani
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Nov 18, 2004·JAMA : the Journal of the American Medical Association·Peter M OkinUNKNOWN LIFE Study Investigators
Nov 18, 2004·JAMA : the Journal of the American Medical Association·Richard B DevereuxBjörn Dahlöf
Dec 14, 2005·Archives of Internal Medicine·Jasper J BrugtsJacqueline C M Witteman
Feb 8, 2006·Annals of Internal Medicine·Mahboob RahmanUNKNOWN ALLHAT Collaborative Research Group

❮ Previous
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Citations

Aug 15, 2013·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Massimo VolpeUNKNOWN Italian Society of Hypertension
Jan 10, 2013·European Heart Journal Cardiovascular Imaging·Gian Francesco MuredduUwe Nixdorff
Apr 9, 2014·Clinical Interventions in Aging·Edelgard Anna KaiserHans Hendrik Schäfer
Sep 17, 2014·Journal of the American Society of Hypertension : JASH·Gary L Schwartz, Lawrence R Krakoff
Jun 20, 2013·Blood Pressure·UNKNOWN Task Force for the management of arterial hypertension of the European Society of Hypertension, UNKNOWN Task Force for the management of arterial hypertension of the European Society of Cardiology
Aug 5, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jong-Ku ParkYeon-Sik Bong
Apr 3, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Anne Marie O'FlynnPatricia M Kearney
Dec 18, 2013·La Presse médicale·Habib Ben AhmedFaika Ben Mami Ben Miled
Sep 9, 2016·Journal of Human Hypertension·D AgnolettiM E Safar
Oct 1, 2016·International Journal of Molecular Sciences·Joaquim Fernández-Solà, Ana Planavila Porta
Mar 24, 2018·The Journal of Clinical Hypertension·Yentl C HaanLizzy M Brewster
Feb 2, 2019·The Journal of Clinical Hypertension·Xueli JiangYuqing Zhang
Mar 29, 2019·Circulation Research·Massimo VolpeGiuliano Tocci
Aug 31, 2018·European Heart Journal·Bryan WilliamsUNKNOWN ESC Scientific Document Group
Nov 7, 2019·The Journal of Clinical Hypertension·Francesca MiceliGiuliano Tocci
Feb 19, 2020·Expert Opinion on Pharmacotherapy·Alexandra KatsimardouVasilios G Athyros
Feb 15, 2013·Journal of Hypertension·Pedro Armario, Bernard Waeber
Sep 14, 2012·Journal of Hypertension·Massimo VolpeAllegra Battistoni
Jan 16, 2016·Journal of Hypertension·Seong Hwan KimChol Shin
Oct 20, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O D Ostroumova, M S Cherniaeva
Jan 4, 2019·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Massimo VolpeGiuliano Tocci

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