Abstract
The purpose of this study was to assess the prevalence of cardiorenal risk factors, their management in a routine clinical setting, and the actual achievement of international guideline targets in a large cohort of type 2 diabetic patients with diabetic nephropathy. A multicentric cross-sectional study was performed in the Campania region in Italy to evaluate cardiorenal risk factors and their management in light of international guidelines. Overall, 28,550 diabetic patients were screened in the 21 participating centers; 847 (348 male and 449 female) patients with type 2 diabetes and a clinical diagnosis of diabetic nephropathy were recruited. Of these subjects, 749 had microalbuminuria and 98 had macroalbuminuria. Targets for blood pressure, HbA(1c), LDL cholesterol, HDL cholesterol, and triglycerides were reached in, respectively, 17.5, 32.3, 30.7, 47, and 55.2% of the patients. Chronic renal failure (glomerular filtration rate <60 ml/min) was revealed in 41% and anemia in 23.8% of the patients. This is the first study to investigate a large cohort of type 2 diabetic patients with early and moderate diabetic nephropathy strictu sensu. Notably, impaired renal function can be often diagnosed in these patients even in the presen...Continue Reading
References
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Dec 1, 1996·Diabetologia·P FiorettoR Nosadini
Aug 6, 1998·The New England Journal of Medicine·D C Brater
Jun 27, 2000·Diabetes·R NosadiniP Fioretto
Dec 9, 2000·BMJ : British Medical Journal·C E MogensenM E Cooper
Sep 22, 2001·The New England Journal of Medicine·E J LewisUNKNOWN Collaborative Study Group
Sep 22, 2001·The New England Journal of Medicine·H H ParvingUNKNOWN Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group
Mar 5, 2002·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Julius M GardinUNKNOWN American Society of Echocardiography
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gianna MazzuccoGuido Monga
Dec 11, 2002·Kidney International·Amanda I AdlerUNKNOWN UKPDS GROUP
Jan 31, 2003·The New England Journal of Medicine·Peter GaedeOluf Pedersen
Jun 5, 2003·Journal of Hypertension·UNKNOWN European Society of Hypertension-European Society of Cardiology Guidelines Committee
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jan 22, 2004·JAMA : the Journal of the American Medical Association·Sharon H SaydahCatherine C Cowie
Mar 19, 2004·QJM : Monthly Journal of the Association of Physicians·N JossJ M Boulton-Jones
Apr 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Luca De NicolaUNKNOWN investigators of the TArget Blood Pressure LEvels in Chronic Kidney Disease (TABLE in CKD) Study Group
Aug 26, 2004·Kidney International·Anupama MohanramRobert D Toto
Nov 2, 2004·The New England Journal of Medicine·William E Mitch
Dec 25, 2004·Diabetes Care·UNKNOWN American Diabetes Association
Citations
Aug 5, 2009·Diabetologia·D KoyaUNKNOWN Low-Protein Diet Study Group
Oct 7, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Rudy Bilous
Nov 18, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ferdinando C SassoUNKNOWN Nephropathy In Type 2 Diabetes Study Group
Feb 10, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roberto MinutoloLuca De Nicola
Nov 22, 2011·Advances in Chronic Kidney Disease·Bernadette Thomas
Mar 18, 2011·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Francisco Javier Del Cañizo GómezAmparo Segura Galindo
May 13, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fausta CatapanoGiuseppe Conte
Feb 19, 2008·Journal of Diabetes and Its Complications·Bin LuRenming Hu
Jul 25, 2007·Diabetes, Obesity & Metabolism·Alireza KhoshdelPaul Trevillian
Feb 17, 2015·Renal Failure·Min ZhangLinhua He
Mar 31, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Teresa K ChenLawrence J Appel
Aug 12, 2014·Acta Diabetologica·Ferdinando Carlo SassoGiuseppe Paolisso
Oct 16, 2014·Clinical Pharmacokinetics·Jia LiXiao-Dong Liu
Mar 12, 2008·Diabetes Care·Ulrike RotheJan Schulze
Aug 27, 2016·PloS One·Chi-Juei JengI-Jong Wang
Oct 14, 2016·Cardiovascular Diabetology·Ferdinando Carlo SassoUNKNOWN NID-2 study group
Nov 9, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Rodolfo NastiFerdinando C Sasso
Mar 17, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Changhwan SeoJung Tak Park
Apr 3, 2019·Lipids in Health and Disease·Xiao-Feng LiChun-Ping Dong
Jun 7, 2012·Clinical Pharmacokinetics·Miroslav DostalekMartina Puzanovova
May 6, 2021·Journal of Clinical Medicine·Nobuko KitagawaMichiaki Fukui
Jun 12, 2021·European Heart Journal. Cardiovascular Pharmacotherapy·Francesco FranchiDominick J Angiolillo
Jul 18, 2021·Cardiovascular Diabetology·Ferdinando Carlo SassoUNKNOWN NID-2 Study Group Investigators
Nov 14, 2020·Clinical Nutrition ESPEN·Yossef Hassan AbdelQadirAnas Zakarya Nourelden
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity