Abstract
Although patients with type 2 diabetes mellitus and cardiovascular disease share common risk factors, the link between these diseases remains largely unexplained. In this case-control study, the earlier use of cardiovascular drugs (before the diagnosis of diabetes) was investigated among cases with type 2 diabetes mellitus and controls without diabetes. Using the PHARMO database, we identified 4,864 patients who were prescribed oral hypoglycaemic agent (OHA) therapy between 1985-1998 in the Netherlands. For each case, two controls matched on age, sex and pharmacy were randomly selected. Controls had not received insulins or OHA therapy. There were 2,656 (55.0%) cases compared with 2,727 (28.1%) controls who used cardiovascular drugs at the start of OHA therapy. Cases had a 3.5-fold increased risk of cardiovascular drug use (OR(95% CI) = 3.5 [3.2-3.8]) compared to controls. Differences in cardiovascular drug use were noted as early as 7 years before the start of OHA therapy, distinguishing cases from controls. Our finding that patients with type 2 diabetes mellitus were more likely to receive treatment for cardiovascular disease several years before they start diabetes therapy supports the hypothesis of a common underlying mecha...Continue Reading
References
Jul 1, 1992·Diabetes Care·M I HarrisM W Knuiman
Feb 1, 1992·Journal of Clinical Epidemiology·M Von KorffK Saunders
May 1, 1991·Diabetologia·A FontbonneE Eschwège
Mar 2, 1991·BMJ : British Medical Journal·V V SalomaaT A Miettinen
Jun 6, 1990·JAMA : the Journal of the American Medical Association·S M HaffnerJ K Patterson
Jul 1, 1989·Diabetes Care·M I Harris
Dec 1, 1988·Diabetes·G M Reaven
Jan 1, 1983·Journal of Chronic Diseases·M RendellL Yamamoto
Sep 11, 1995·Archives of Internal Medicine·R M HeringsF Sturmans
Apr 1, 1995·Diabetes·M P Stern
Oct 1, 1994·Journal of Clinical Epidemiology·H Glauber, J Brown
Apr 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·P A GrootenhuisL M Bouter
Aug 1, 1994·Diabetes·J KuusistoM Laakso
Oct 1, 1993·Diabetologia·E Standl, H Stiegler
Jun 1, 1993·Diabetologia·L MykkänenM Laakso
Mar 1, 1993·European Journal of Epidemiology·R P StolkD E Grobbee
Apr 1, 1997·Diabetes Care·K PyŏräläG Thorgeirsson
Jun 1, 1997·Diabetologia·S M HaffnerM P Stern
Jun 1, 1997·International Journal of Epidemiology·A Fagot-CampagnaE Eschwège
Apr 16, 1998·Diabetes Care·B BalkauE Eschwège
Aug 7, 1998·Atherosclerosis·M Laakso, S Lehto
Sep 11, 1998·BMJ : British Medical Journal
Citations
Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·M LeschkeM Faehling
May 27, 2004·Diabetes Care·Dean T EurichJeffrey A Johnson
Nov 21, 2002·Current Opinion in Lipidology·Fahmy W F Hanna