Cardiovascular risk factors in Chiari malformation and idiopathic intracranial hypertension

Brain and Behavior
Radek FričPer Kristian Eide

Abstract

Both Chiari malformation type 1 (CMI, i.e., the idiopathic caudal ectopy of cerebellar tonsils into foramen magnum) and idiopathic intracranial hypertension (IIH) are characterized by reduced intracranial compliance (ICC) due to disturbed circulation of cerebrospinal fluid (CSF). An increasing body of evidence links cardiovascular disease to CSF circulation disturbances. The aim of this study was to explore whether the prevalence of cardiovascular risk factors in patients with CMI or IIH is higher than in the general population. Among the patients with CMI or IIH treated at our department during the period 2003-2014, we identified those with history of arterial hypertension (AH), myocardial infarction (MI), angina pectoris (AP), or diabetes mellitus (DM). For comparison with a control population, we retrieved information about the prevalence of AH, MI, AP, and DM among participants of the North-Trøndelag Health Study 3 (HUNT3). Data from 48 CMI and 52 IIH cases were available. Compared to data from the 42,461 individuals participating in the HUNT3, we found increased prevalence of DM in male CMI as well as female IIH cases, and of AH in female IIH cases. Body mass index (BMI) was significantly increased in both female and male ...Continue Reading

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Citations

Aug 9, 2019·Journal of Neuropathology and Experimental Neurology·Md Mahdi Hasan-OlivePer Kristian Eide
May 17, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Federica Novegno
Jan 17, 2020·British Journal of Neurosurgery·Luis Rafael Moscote-SalazarHarold Vasquez
Oct 28, 2019·Acta neurochirurgica·Radek Frič, Per Kristian Eide
Jul 9, 2021·Brain Communications·Per Kristian EideLars Magnus Valnes
Aug 30, 2021·Clinical Neurology and Neurosurgery·Frances Tiffany Cava MordenArash Ghaffari-Rafi

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Key Resources (RRID) Mentioned

SCR_002865
SCR_01276

Software Mentioned

SPSS
Stata

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