Abstract
To examine the relationship of corneal arcus with cardiovascular risk factors and inflammation in Malay adults living in Singapore. Population-based cross-sectional study. A total of 3280 Malays aged 40-80 years (out of 4168 eligible participants; 78.7% response rate) had a standardized interview, systemic and ocular examinations, and laboratory investigations, including measurement of C-reactive protein (CRP), chronic kidney disease, and peripheral artery disease. Corneal arcus was defined from anterior segment images taken with a slit-lamp camera. Corneal arcus was seen in 2345 out of 3260 participants who had anterior segment images (73.2%). After adjustment for age, gender, total cholesterol, serum glucose, and current smoking, many cardiovascular risk factors significantly associated with corneal arcus, including male gender (odds ratio [OR] 1.65, 95% confidence interval [CI] 1.27-2.03), older age (per 10 years, OR 4.49, 95% CI 3.91-5.15), higher body mass index (per kg/m(2), OR 1.02, 95% CI 1.00-1.04), higher levels of CRP (per 10 mg/L, OR 1.36, 95% CI 1.13-1.64), total cholesterol (per mmol/L, OR 1.21, 95% CI 1.11-1.32), low-density lipoprotein cholesterol (per mmol/L, OR 1.94, 95% CI 1.38-2.74), presence of peripheral a...Continue Reading
References
Jun 1, 1992·International Journal of Epidemiology·K HughesP B Yeo
Jul 1, 1991·Survey of Ophthalmology·B J BarchiesiP P Ellis
Oct 1, 1990·American Journal of Public Health·L E ChamblessB M Rifkind
Dec 19, 1974·The New England Journal of Medicine·R H RosenmanC D Jenkins
Jul 1, 1970·British Heart Journal·N HickeyR Mulcahy
Dec 1, 1965·American Heart Journal·G M McAndrew, D Ogston
Aug 1, 1984·The British Journal of Ophthalmology·S T HalfonS Heyden
Jan 23, 1999·Clinical Genetics·A F WinderP F Butowski
Feb 6, 1965·Lancet·B M RIFKIND
Feb 14, 2004·American Journal of Ophthalmology·Brian E ChuaElena Rochtchina
Apr 9, 2004·The New England Journal of Medicine·John DaneshVilmundur Gudnason
Jun 20, 2006·Autoimmunity Reviews·Anna Abou-Raya, Suzan Abou-Raya
Oct 20, 2006·Atherosclerosis·Antonio FernándezPaul D Thompson
Mar 17, 2007·Ophthalmic Epidemiology·Athena W P FoongTien Y Wong
Dec 25, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anoop ShankarTien Yin Wong
Feb 1, 2008·Investigative Ophthalmology & Visual Science·Ecosse L LamoureuxTien Yin Wong
Jun 20, 2008·Atherosclerosis·Yasmin S HamiraniKhurram Nasir
Jul 1, 2008·Ophthalmology·Tien Y WongPaul Mitchell
Aug 13, 2008·Archives of Ophthalmology·Tien Yin WongUNKNOWN Singapore Malay Eye Study Team
Dec 19, 2008·American Journal of Epidemiology·Charumathi SabanayagamTien Yin Wong
Dec 23, 2008·The American Journal of Cardiology·Antonio B FernandezPaul D Thompson
Jan 6, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·George A Kaysen
Jun 11, 2009·The Journal of Clinical Endocrinology and Metabolism·Ronald B Goldberg
Jul 22, 2009·Journal of Hypertension·Charumathi SabanayagamTien Y Wong
Aug 8, 2009·The American Journal of Cardiology·Mark HamerEmmanuel Stamatakis
Aug 21, 2009·American Journal of Physiology. Renal Physiology·Michal Chmielewski, Boleslaw Rutkowski
Aug 27, 2009·The American Journal of the Medical Sciences·Hung-Ta ChenKen-Kuo Lin
Sep 10, 2009·Circulation·David ConenAruna D Pradhan
Mar 9, 2010·Heart & Lung : the Journal of Critical Care·Nilüfer Ekşi DuranMehmet Ozkan
Citations
Nov 22, 2015·Ageing Research Reviews·Mette Christoffersen, Anne Tybjærg-Hansen
Jul 12, 2011·American Journal of Ophthalmology·Marcus AngTien Yin Wong
Aug 15, 2014·Ophthalmic Epidemiology·Hassan HashemiAkbar Fotouhi
Jan 1, 2012·JRSM Cardiovascular Disease·Amitesh AggarwalShridhar Dwivedi
Dec 29, 2020·Seminars in Ophthalmology·Sohaib R RufaiV Jayshree Menon