Cardiovascular risk in advanced naïve HIV-infected patients starting antiretroviral therapy: Comparison of three different regimens - PREVALEAT II cohort

Atherosclerosis
Paolo MaggiGioacchino Angarano

Abstract

PREVALEAT (PREmature VAscular LEsions and Antiretroviral Therapy) II is a multicenter, longitudinal cohort study aimed at the evaluation of cardiovascular risk among advanced HIV-positive, treatment-naïve patients starting their first therapy. We hypothesized that these patients, present a higher cardiovascular (CV) risk. The study included all consecutive naïve patients with less than 200 CD4 cells/ml starting antiretroviral therapy. Our primary objective was to evaluate changes in carotid intima- media thickness (IMT). Secondary endpoints included changes in flow mediated vasodilation (FMD), inflammatory markers, triglycerides and cholesterol. Patients were evaluated at time 0, and after 3, 6 and 12 months. We enrolled 119 patients, stratified into three different groups: patients receiving atazanavir/ritonavir boosted (ATV/r) based regimens, efavirenz (EFV) based regimens and darunavir/ritonavir boosted (DRV/r) based regimens. At baseline, advanced naïve patients showed a relevant deterioration of CV conditions in terms of traditional CV risk factors, endothelial dysfunction and serum biomarkers. During the 12-month follow up period, mean blood lipids significantly increased: total cholesterol from 159 to 190 mg/dL, HDL-C fr...Continue Reading

Citations

Jan 22, 2019·Journal of Cardiovascular Medicine·Mattia PeyracchiaFabrizio D'Ascenzo
Dec 13, 2019·The Journal of Infectious Diseases·Virginia A Triant, Mark J Siedner
Nov 19, 2019·Open Forum Infectious Diseases·Elizabeth S Mayne, Susan Louw
May 29, 2021·Expert Opinion on Drug Safety·Camilla Ingrid HatlebergCaroline Sabin
Jul 3, 2021·Viruses·Matthias ClaussNavneet Dhillon

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