Cardiovascular risk in chronic kidney disease: what is new in the pathogenesis and treatment?

Postgraduate Medicine
Angelika BazylukEdyta Zbroch

Abstract

The prevalence of chronic kidney disease (CKD) has increased markedly over past decades due to the aging of the worldwide population. Despite the progress in the prevention and treatment, the cardiovascular (CV) morbidity and mortality remain high among patients with CKD. Although CKD is a progressive and irreversible condition, it is possible to slow decreasing kidney function, as well as the development and progression of associated with kidney disease comorbidities. Diabetes mellitus has become major cause of CKD worldwide. It is estimated that the prevalence of diabetes will increase from 425 million worldwide in 2017 to 629 million by 2045, substantially the percentage of diabetic nephropathy among CKD patients is set to rise markedly. The results of multicenter trials concerning novel antidiabetic drugs suggest that efficacy in reducing CV risk is independent of the improvement in glycemic control. This review discusses underlying causes of high CV risk and strategies reducing individual burden among CKD patients.

References

Jul 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K A Nath
Mar 14, 2003·European Heart Journal·J F E MannJ Franke
Aug 5, 2003·The Journal of Clinical Investigation·Cora SchaferWilli Jahnen-Dechent
Mar 20, 2004·Experimental & Molecular Medicine·Ji-Won LeeKyu-Won Kim
Aug 9, 2005·Cardiology Clinics·Ravinder K Wali, William L Henrich
Oct 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Evangelia DounousiDimitrios Tsakiris
Feb 3, 2007·Journal of the American Society of Nephrology : JASN·Masaaki InabaUNKNOWN Osaka CKD Expert Research Group
Apr 26, 2007·Diabetes Care·Prataap K Chandie ShawTon J Rabelink
Jun 2, 2007·NMR in Biomedicine·Torill E SjøbakkIngrid S Gribbestad
Feb 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jiaqiong XuBarbara V Howard
Jul 18, 2008·Diabetes·Norbert StefanMatthias B Schulze
Aug 13, 2008·Archives of Internal Medicine·Norbert StefanHans-Ulrich Häring
Nov 11, 2008·Trends in Genetics : TIG·Ana Maria Cuervo
Nov 26, 2008·Circulation·Cornelia WeikertAndreas Fritsche
Dec 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Douglas M Silverstein
Jan 21, 2009·European Journal of Applied Physiology·Luciano A SilvaRicardo A Pinho
Jan 24, 2009·Kidney International·Andrew M SiedleckiAnthony J Muslin
Feb 17, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Christiane DrechslerUNKNOWN NECOSAD Study Group
May 30, 2009·Journal of the American Society of Nephrology : JASN·Masahide MizobuchiEduardo Slatopolsky
Jul 21, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tadao AkizawaUNKNOWN CAP-KD Study Group
Nov 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sophie LiabeufUNKNOWN European Uraemic Toxin Work Group (EUTox)
Jan 9, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Richard J GlassockSilvio H Barberato
Jan 1, 2010·The Review of Diabetic Studies : RDS·Baptist Gallwitz
Jun 12, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Marian GoicoecheaJosé Luño
Jul 24, 2010·Pflügers Archiv : European journal of physiology·Gisela DrewsMartina Düfer
Oct 5, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I-Wen WuMai-Szu Wu
Nov 6, 2010·Diabetologia·T M E DavisUNKNOWN Fenofibrate Intervention and Event Lowering in Diabetes Study investigators
Nov 10, 2010·BMJ : British Medical Journal·Braden MannsUNKNOWN Alberta Kidney Disease Network
Oct 21, 2011·The Journal of Clinical Endocrinology and Metabolism·Ajay ChaudhuriParesh Dandona
Nov 15, 2011·Cell·Noboru Mizushima, Masaaki Komatsu
Dec 24, 2011·Journal of the American Society of Nephrology : JASN·Davide P CinàSusan E Quaggin
Nov 10, 2012·Circulation Research·Suree LekawanvijitHenry Krum
Jan 24, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Patrick Steven TuckerMichael Ian Kingsley
Mar 14, 2013·International Urology and Nephrology·Sylwia Olechnowicz-TietzJacek Rysz

❮ Previous
Next ❯

Citations

Sep 11, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yijian ZhangBin Pi
May 7, 2021·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·Lívia Torres MedeirosClaudia Maria Costa de Oliveira
Jul 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ghedeir M AlshammariMohammed Abdo Yahya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Related Papers

Postgraduate Medical Journal
Elias C ChackoJoseph M Pappachan
Seminars in Dialysis
Tejas Patel, David M Charytan
British Medical Bulletin
T Z MinR A Chudleigh
© 2022 Meta ULC. All rights reserved