Cardiovascular risk markers in patients with primary aldosteronism: A systematic review and meta-analysis of literature studies

International Journal of Cardiology
Pasquale AmbrosinoMatteo Nicola Dario Di Minno

Abstract

Several studies reported an increased cardiovascular (CV) morbidity and mortality in patients with primary aldosteronism (PA). We performed a meta-analysis on the impact of PA on major markers of CV risk. Studies on the relationship between PA and common carotid artery intima-media thickness (CCA-IMT), prevalence of carotid plaques, flow-mediated dilation (FMD), nitrate-mediated dilation (NMD), pulse-wave velocity (PWV), augmentation index (AIx), and ankle-brachial index (ABI) were systematically searched in the PubMed, Web of Science, Scopus and EMBASE databases. 12 case-control studies (445 cases, 472 controls) were included. Compared to subjects with essential hypertension (EH), PA patients showed a higher CCA-IMT (MD: 0.12 mm; 95% CI: 0.09, 0.16; P<0.00001), and a higher aortic-PWV (272 cases and 240 controls, MD: 1.39 m/s; 95% CI: 0.90, 1.87; P<0.00001). In contrast, non-significant differences were found in AIx and AIx normalized to a heart rate of 75 beats per minute (AIx@75). When compared to normotensive subjects, PA patients showed significantly higher CCA-IMT (MD: 0.16 mm; 95% CI: 0.05, 0.27; P=0.004), aortic-PWV (MD: 3.74 m/s; 95% CI: 3.43, 4.05; P<0.00001), AIx@75 (MD: 8.59%; 95% CI: 0.69, 16.50; P=0.03), and a sig...Continue Reading

References

Nov 1, 1996·Hypertension·D RizzoniE Agabiti-Rosei
Feb 28, 2002·QJM : Monthly Journal of the Association of Physicians·I S MackenzieJ R Cockcroft
Oct 17, 2002·Annals of the New York Academy of Sciences·Ricardo Rocha, John W Funder
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Mar 3, 2004·Hypertension·Hans OberleithnerHermann Schillers
Jun 17, 2004·Circulation·Eric de GrootJohn J P Kastelein
Apr 13, 2006·The Journal of Clinical Endocrinology and Metabolism·Damiano RizzoniEnrico Agabiti Rosei
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·David A Calhoun
Jan 16, 2008·Archives of Internal Medicine·Cristiana CatenaLeonardo A Sechi
Mar 4, 2008·Trends in Endocrinology and Metabolism : TEM·Gian-Paolo RossiJohn W Funder
Sep 11, 2008·Clinical Cardiology·Costas TsioufisIoannis Kallikazaros
Apr 9, 2009·Endocrine Journal·Kyoichiro TsuchiyaYukio Hirata
May 1, 2008·Current Cardiology Reviews·Tahir H KhanKhusrow Niazi
Apr 19, 2011·Cardiovascular Ultrasound·Jordi CalabiaMartí Vallés
Jul 5, 2011·Molecular and Cellular Endocrinology·Amy McCurley, Iris Z Jaffe
Aug 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Vin-Cent WuUNKNOWN TAIPAI Study Group
Nov 19, 2011·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C CatenaL A Sechi
Jul 25, 2012·Hypertension·Martin ReinckeUNKNOWN German Conn's Registry-Else Kröner-Fresenius-Hyperaldosteronism Registry
Aug 15, 2012·Kidney & Blood Pressure Research·J WidimskyR Holaj
Oct 9, 2012·International Journal of Cardiology·Rouyanne T RasPeter L Zock
Mar 22, 2014·The Korean Journal of Internal Medicine·Sun Hwa KimDong Seop Choi
Aug 16, 2014·World Journal of Diabetes·Iciar Martín-TimónFrancisco Javier Del Cañizo-Gómez
Aug 22, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yi-Yao ChangUNKNOWN TAIPAI Study Group
Dec 10, 2014·Journal of Hypertension·Robert HolajJiří Widimský
May 9, 2015·Annals of Medicine·Matteo Nicola Dario Di MinnoElena Tremoli
Nov 9, 2015·European Journal of Internal Medicine·Matteo Nicola Dario Di MinnoElena Tremoli
Dec 25, 2015·Journal of the American Heart Association·Alessia BuglioniJohn C Burnett

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Citations

Oct 13, 2018·Clinical and Experimental Hypertension : CHE·Mo-Li ZhuYa-Ling Yin
Jan 24, 2018·Cardiovascular Research·Chia-Hung ChouUNKNOWN TAIPAI Study Group
Jan 14, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Christian LottspeichChristian Adolf
Mar 23, 2021·European Journal of Clinical Investigation·Pasquale AmbrosinoMatteo Nicola Dario Di Minno

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