Cardiovascular risk profile of patients with psoriatic arthritis compared to controls--the role of inflammation

Rheumatology
L-S TamE K Li

Abstract

To examine the distribution of traditional and novel risk factors of cardiovascular disease (CVD) in patients with PsA compared with healthy controls. We compared risk factors for CVD between 102 consecutive PsA patients and 82 controls, adjusting for BMI. We also assessed the role of inflammation on the CVD risk factor by using a BMI and high-sensitivity CRP (hsCRP)-adjusted model. The BMI of PsA patients were significantly higher than healthy controls. After adjusting for the BMI, PsA patients still have a higher prevalence of diabetes mellitus (DM) [odds ratio (OR) 9.27, 95% CI 2.09, 41.09) and hypertension (OR 3.37, 95% CI 1.68, 6.72), but a lower prevalence of low high density lipoprotein (HDL) cholesterol (OR 0.16, 95% CI 0.07, 0.41). PsA patients have significantly increased systolic and diastolic blood pressures, insulin resistance and inflammatory markers (hsCRP and white cell count) compared to controls. PsA patients have higher HDL cholesterol and apolipoprotein (Apo) A1 levels; and lower total cholesterol (TC) and low density lipoprotein cholesterol levels; and a lower TC/HDL ratio. However, the Apo B level (P < 0.05), and the Apo B/Apo A1 ratio (P = 0.07) were higher in PsA patients. Further adjustment for hsCRP le...Continue Reading

Citations

Jan 17, 2012·Clinical Rheumatology·Boulos HaraouiKim A Papp
Apr 8, 2011·Journal of General Internal Medicine·Rita V PatelRobert S Kirsner
May 10, 2011·Current Rheumatology Reports·Ying-Ying LeungEdmund K Li
Feb 24, 2012·Clinical Reviews in Allergy & Immunology·David SiegelIshwarlal Jialal
Feb 3, 2009·Nature Clinical Practice. Rheumatology·Kristine E NogralesAnne M Bowcock
Aug 29, 2009·Rheumatology·Lai-Shan TamEdmund K Li
May 23, 2009·Current Opinion in Rheumatology·Juergen Braun, Xenofon Baraliakos
Jan 5, 2011·International Journal of Rheumatic Diseases·Fabrizio CantiniEmanuele Cassarà
May 16, 2012·Annals of the Rheumatic Diseases·Thorvardur Jon LoveHyon K Choi
May 31, 2012·International Journal of Rheumatology·Tracy Y ZhuLai-Shan Tam
Nov 11, 2010·Indian Journal of Dermatology·Anupam Prakash, Deepshikha
Aug 3, 2013·Clinical Medicine : Journal of the Royal College of Physicians of London·Awal Alhusain, Ian N Bruce
Nov 12, 2013·Metabolic Syndrome and Related Disorders·Seval PehlevanNurhan Ince
Jul 12, 2013·Dermatology Research and Practice·Jacob DreiherArnon D Cohen
Jul 22, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Sylvain MathieuMartin Soubrier
Sep 6, 2013·Clinical Rheumatology·Francesco UrsiniRosa Daniela Grembiale
Aug 21, 2009·Current Rheumatology Reports·Ignazio OlivieriSimona de Portu
May 4, 2010·Current Rheumatology Reports·Vinod Chandran, Dafna D Gladman
May 12, 2012·Current Rheumatology Reports·Amir Haddad, Vinod Chandran
Oct 1, 2014·Journal of Neuroimmunology·Réza Behrouz
Jun 9, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Jiayun ShenLai-Shan Tam
Jun 5, 2013·Joint, Bone, Spine : Revue Du Rhumatisme·Charalampos PapagorasAlexandros A Drosos
Jun 6, 2012·Journal of the American Academy of Dermatology·Jashin J WuLisa J Herrinton
Oct 26, 2011·The Journal of Sexual Medicine·Shiu-Dong ChungHerng-Ching Lin
Mar 20, 2012·Best Practice & Research. Clinical Rheumatology·Michael Ehrenfeld
Mar 20, 2012·Best Practice & Research. Clinical Rheumatology·Gleison Vieira DuarteJozélio Freire de Carvalho
Jun 21, 2011·Autoimmunity Reviews·R RamondaA Doria
Sep 8, 2010·Diabetes Research and Clinical Practice·M TakaharaM Matsuhisa
Aug 25, 2009·Journal of the American Academy of Dermatology·Maryanne MakredesAlexa B Kimball
Jan 27, 2009·Journal of the American Academy of Dermatology·Kristina Callis DuffinGerald G Krueger
Oct 18, 2015·Rheumatic Diseases Clinics of North America·Alexis Ogdie, Pamela Weiss
Aug 19, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·G Girolomoni, P Gisondi
Sep 2, 2008·Arthritis and Rheumatism·Lai-Shan TamCheuk-Man Yu
Feb 19, 2009·Dermatologic Therapy·Mariya Rozenblit, Mark Lebwohl
Jun 19, 2013·The British Journal of Dermatology·P Coto-SeguraE Coto
Jul 17, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·C HorreauM-A Richard
Jul 4, 2012·Cell Biochemistry and Function·Houshang NematiKamran Eftekhari
Feb 26, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·Q YangF Zhang
Apr 27, 2010·Dermatologic Therapy·Aldona PietrzakJana Hercogová
Apr 27, 2010·Dermatologic Therapy·Mohammed Ahmed AlsufyaniMark Lebwohl
Aug 8, 2015·La Presse médicale·Sylvain Mathieu, Martin Soubrier
Jan 15, 2014·La Revue de médecine interne·Y BenhamouR Joannidès
Apr 12, 2016·Journal of Clinical Laboratory Analysis·Zhen-Xing ZhouTian-Cheng Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.