Cardiovascular Risks of Probenecid Versus Allopurinol in Older Patients With Gout

Journal of the American College of Cardiology
Seoyoung C KimDaniel H Solomon

Abstract

Patients with gout are at an increased risk of cardiovascular (CV) disease including myocardial infarction (MI), stroke, and heart failure (HF). The authors conducted a cohort study to examine comparative CV safety of the 2 gout treatments-probenecid and allopurinol-in patients with gout. Among gout patients ≥65 years of age and enrolled in Medicare (2008 to 2013), those who initiated probenecid or allopurinol were identified. The primary outcome was a composite CV endpoint of hospitalization for MI or stroke. MI, stroke, coronary revascularization, HF, and mortality were assessed separately as secondary outcomes. The authors estimated the incidence rate and hazard ratio of the primary and secondary outcomes in the 1:3 propensity score-matched cohort of probenecid and allopurinol initiators. A total of 9,722 probenecid initiators propensity score-matched to 29,166 allopurinol initiators with mean age of 76 ± 7 years, and 54% males were included. The incidence rate of the primary composite endpoint of MI or stroke per 100 person-years was 2.36 in probenecid and 2.83 in allopurinol initiators with a hazard ratio of 0.80 (95% confidence interval: 0.69 to 0.93). In the secondary analyses, probenecid was associated with a decreased ...Continue Reading

Citations

Jan 3, 2019·Current Opinion in Rheumatology·Thomas Bardin, Pascal Richette
Jan 3, 2019·Current Opinion in Rheumatology·Aryeh M Abeles, Michael H Pillinger
Feb 15, 2019·Diabetes, Obesity & Metabolism·Clifford J Bailey
Sep 27, 2019·The Journal of Clinical Hypertension·Shingo HigaKazuomi Kario
Dec 17, 2019·Current Opinion in Rheumatology·Abhishek Abhishek
Feb 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiaojiao HanXiurong Su
Mar 30, 2019·Current Opinion in Cardiology·Matteo Landolfo, Claudio Borghi
Oct 26, 2018·Circulation·William B White
Jul 26, 2019·Current Rheumatology Reports·Eun Ha Kang, Seoyoung C Kim
Dec 21, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yuko IwataMasafumi Kitakaze
Feb 25, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Mallory T MouradjianSandeep Devabhakthuni
Oct 22, 2020·The New England Journal of Medicine·Claudio Ponticelli, Manuel A Podestà
Jun 23, 2020·Progress in Biophysics and Molecular Biology·Brian O'ConnorJack Rubinstein
Jan 6, 2021·Current Opinion in Rheumatology·Kazuki YoshidaDaniel H Solomon
Oct 22, 2020·The New England Journal of Medicine·Sunil V BadveDavid W Johnson
Oct 22, 2020·The New England Journal of Medicine·Natalie McCormickHyon K Choi
Mar 2, 2021·Circulation Research·Miranda E GoodBrant E Isakson
Jun 12, 2021·Expert Review of Cardiovascular Therapy·Asma GulabJanani Rangaswami
Jun 13, 2021·Cardiovascular Research·Zsófia OnódiZoltán V Varga
Dec 19, 2018·Journal of Agricultural and Food Chemistry·Naixin LiuXinwang Yang
Sep 12, 2021·European Heart Journal·Eun Ha KangSeoyoung C Kim
Dec 19, 2021·Nature Reviews. Rheumatology·Hyon K ChoiChio Yokose
Dec 23, 2021·Expert Opinion on Pharmacotherapy·Kurt E G BlakeKenneth G Saag

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.