Cardiovascular safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients: a prospective evaluation

Future Oncology
Veronica PratiCinzia Ortega

Abstract

The aim of this study is to evaluate cardiotoxicity of abiraterone acetate (AA) in metastatic castration-resistant prostate cancer patients (pts) with cardiovascular comorbidities or coronary artery disease (CAD) risk factors. We prospectively analyzed pts receiving AA in order to evaluate correlations between cardiotoxicity onset and CAD risk factors or cardiovascular comorbidities. Eighty-seven pts were enrolled, with median treatment duration of 9 months (1-44). At baseline, 84 pts (96%) had CAD risk factors. During treatment four pts (4; 6%) developed hypertension and 26 pts (30%) worsened the preexisting hypertension. Median left ventricular ejection fraction were 64 and 63% at baseline and after treatment, respectively. AA appears to be safe in pts with cardiovascular comorbidities or CAD risk factors.

References

Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Sep 26, 2013·American Journal of Clinical Oncology·Giuseppe ProcopioFilippo de Braud
Feb 25, 2014·American Journal of Men's Health·Jeannie J SuT Mike Hsieh
May 27, 2014·American Society of Clinical Oncology Educational Book·Cora N SternbergChris Parker
Jul 15, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Roberto IacovelliFranco Nolè
Jul 25, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C ParkerUNKNOWN ESMO Guidelines Committee
Jan 7, 2016·Journal of the National Comprehensive Cancer Network : JNCCN·James L MohlerDeborah A Freedman-Cass

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