Cardiovascular safety of tocilizumab: A systematic review and network meta-analysis

PloS One
Benjamin CastagnéMartin Soubrier

Abstract

Our objective was to compare the cardiovascular safety of tocilizumab and other biological disease-modifying antirheumatic drugs (bDMARD) in rheumatoid arthritis using a network meta-analysis (NMA). A systematic literature search through May 2018 identified randomized controlled trials (RCT) or observational studies (cohort only) reporting cardiovascular outcomes of tocilizumab (TCZ) and/or abatacept (ABA) and/or rituximab (RTX) and/or tumor necrosis factor inhibitors (TNFi) in rheumatoid arthritis patients. The composite primary outcome was the rate of major adverse cardiovascular outcomes (MACE, myocardial infarction (MI), peripheral artery disease (PAD) and cardiac heart failure (CHF)). 19 studies were included in the NMA, including 11 RCTs and 8 cohort studies. We found less events with RTX (5.41 [1.70;17.26]. We found no difference between TCZ and other treatments. Concerning MI, we found no difference between TCZ and csDMARD (4.23 [0.22;80.64]), no difference between TCZ and TNFi (2.00 [0.18;21.84]). There was no difference between TCZ and csDMARD (1.51[0.02;103.50] and between TCZ and TNFi (1.00 [0.06;15.85]) for stroke event. With cohorts and RCT NMA, we found no difference between TCZ and other treatments for MACE (0.6...Continue Reading

References

Aug 15, 2002·Annals of the Rheumatic Diseases·P GeborekUNKNOWN South Swedish Arthritis Treatment Group
Apr 1, 2005·Annals of the Rheumatic Diseases·F GuilleminJ Coste
Apr 19, 2005·Annals of the Rheumatic Diseases·J P FranklinA J Silman
Aug 15, 2006·Statistics in Medicine·Stephen Senn
Nov 28, 2008·Arthritis and Rheumatism·J Antonio Aviña-ZubietaDiane Lacaille
Jun 11, 2009·JAMA : the Journal of the American Medical Association·Pia R KamstrupBørge G Nordestgaard
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Dec 15, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Ziyad Al-AlySeth Eisen
Mar 11, 2011·Annals of the Rheumatic Diseases·Jesper LindhardsenPeter Riis Hansen
Mar 17, 2012·Lancet·UNKNOWN IL6R Genetics Consortium Emerging Risk Factors CollaborationJohn Danesh
Apr 16, 2013·Cytokine·Daniel R AndersonGeoffrey M Thiele
Jun 28, 2013·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Sofia DiasA E Ades
Jun 28, 2013·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Sofia DiasA E Ades
Jun 12, 2014·European Heart Journal·Henning JansenHeribert Schunkert
Oct 11, 2014·Seminars in Arthritis and Rheumatism·Jeffrey R CurtisUNKNOWN Actemra Pharmacoepidemiology Board
Dec 1, 2012·Research Synthesis Methods·Gerta Rücker
Jan 23, 2016·Annals of the Rheumatic Diseases·Jie ZhangJeffrey R Curtis
Apr 16, 2016·Seminars in Arthritis and Rheumatism·Christina Charles-SchoemanRichard Riese

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Citations

Jan 17, 2020·British Journal of Pharmacology·Antigone LazouIoanna Andreadou
Apr 14, 2020·Journal of Cardiovascular Pharmacology·Dave L DixonAntonio Abbate
Jun 20, 2020·Journal of Clinical Pharmacology·Sajad KhialiTaher Entezari-Maleki
Jul 13, 2020·Clinical Rheumatology·Sakir AhmedArmen Yuri Gasparyan
Jun 26, 2020·Journal of Clinical Medicine·Vincenzo RussoGerardo Nigro
Oct 11, 2020·International Journal of Molecular Sciences·Przemysław J KotylaMałgorzata Engelmann
Mar 9, 2021·Stroke; a Journal of Cerebral Circulation·Audrey C LeasureKevin N Sheth
Oct 13, 2020·Atherosclerosis·Zohaib IqbalUNKNOWN Heart UK's Medical Scientific and Research Committee
May 6, 2021·Rheumatology·Benjamin ClarkeJames Galloway
May 18, 2021·Journal of the American Heart Association·Yook Chin ChiaMichele F Eisenga
Aug 19, 2021·Stroke; a Journal of Cerebral Circulation·João Pedro MartoPatrik Michel
Aug 24, 2021·International Journal of Rheumatology·Toka AlsulaimAbdullah Almutlaq

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Software Mentioned

Cochrane Risk Of Bias tool ( RoB
netmeta
R Language and Environment for Statistical Computing
meta
Cochrane Risk Of Bias Non of Interventions ( ROBINS - I
R

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