Cardiovascular symptoms in patients with systemic mast cell activation disease

Translational Research : the Journal of Laboratory and Clinical Medicine
Ulrich W KolckG J Molderings

Abstract

Traditionally, mast cell activation disease (MCAD) has been considered as just one rare (neoplastic) disease, mastocytosis, focused on the mast cell (MC) mediators tryptase and histamine and the suggestive, blatant symptoms of flushing and anaphylaxis. Recently another form of MCAD, the MC activation syndrome, has been recognized featuring inappropriate MC activation with little to no neoplasia and likely much more heterogeneously clonal and far more prevalent than mastocytosis. Increasing expertise and appreciation has been established for the truly very large menagerie of MC mediators and their complex patterns of release, engendering complex, nebulous presentations of chronic and acute illness best characterized as multisystem polymorbidity of generally inflammatory ± allergic theme. We describe the pathogenesis of MCAD with a particular focus on clinical cardiovascular symptoms and the therapeutic options for MC mediator-induced cardiovascular symptoms.

References

Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·G B ProctorR E Smith
Feb 1, 1990·Circulation Research·K RakusanP Wicker
Oct 31, 1985·The New England Journal of Medicine·M B FormanR Virmani
Oct 9, 1986·The New England Journal of Medicine·A M Dvorak
Dec 11, 1980·The New England Journal of Medicine·L J RobertsJ A Oates
Dec 1, 1984·Prostaglandins·D J HeaveyC T Dollery
Jul 1, 1995·Circulation Research·M ImamuraR Levi
Jan 27, 1998·Mayo Clinic Proceedings·E A McElroyC Y Li
Nov 4, 2000·Expert Opinion on Investigational Drugs·C J Mackins, R Levi
May 30, 2001·Leukemia Research·P ValentJ M Bennett
Feb 6, 2002·The Journal of Experimental Medicine·Masatake HaraAkira Matsumori
Jun 27, 2002·The Journal of General Physiology·Annalisa BucchiDario DiFrancesco
May 6, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jacob JosephRichard H Kennedy
Sep 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Randi B SilverRoberto Levi
Feb 8, 2005·Atherosclerosis·Efthymios N DeliargyrisTheoharis C Theoharides
Feb 16, 2005·Hypertension·Cyndya ShibaoItalo Biaggioni
Jun 9, 2005·Annals of Emergency Medicine·Susan M RohrKevin H Silver
Sep 20, 2005·International Journal of Cardiology·Helena KervinenPetri T Kovanen
Nov 8, 2005·Biological & Pharmaceutical Bulletin·Suresh Palaniyandi SelvarajYoshifusa Aizawa
Feb 4, 2006·The Journal of Allergy and Clinical Immunology·Calman Prussin, Dean D Metcalfe
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Michael F Gurish, Joshua A Boyce
Mar 1, 1991·The Journal of Investigative Dermatology·L J Roberts, J A Oates
Jul 11, 2006·European Journal of Heart Failure·Alessandra VultaggioSergio Romagnani
Sep 12, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Montserrat BatlleWladimiro Jimenez
Oct 3, 2006·Journal of the American College of Cardiology·Jiyoong KimMasafumi Kitakaze
Nov 7, 2006·Clinical Reviews in Allergy & Immunology·Peter Peachell
Mar 14, 2007·Journal of the American College of Cardiology·Ulrich W KolckGerhard J Molderings
May 8, 2007·The Journal of Allergy and Clinical Immunology·Melody C CarterDean D Metcalfe
May 15, 2007·Immunological Reviews·Alicia C ReidRoberto Levi
Aug 22, 2007·Scandinavian Journal of Gastroenterology·Gerhard J MolderingsIvar Von Kügelgen
Jan 4, 2008·Nature Reviews. Drug Discovery·Robin L ThurmondPaul J Dunford
Feb 10, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Shahriar Iravanian, Samuel C Dudley
Jul 9, 2008·Circulation·Hirokazu HiguchiAkira Matsumori
Jan 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E OnoK Akiyama

❮ Previous
Next ❯

Citations

Mar 27, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Lawrence B Afrin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.