PMID: 11913479Mar 27, 2002Paper

Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload

European Heart Journal
L J AndersonD J Pennell

Abstract

To develop and validate a non-invasive method for measuring myocardial iron in order to allow diagnosis and treatment before overt cardiomyopathy and failure develops. We have developed a new magnetic resonance T2-star (T2*) technique for the measurement of tissue iron, with validation to chemical estimation of iron in patients undergoing liver biopsy. To assess the clinical value of this technique, we subsequently correlated myocardial iron measured by this T2* technique with ventricular function in 106 patients with thalassaemia major. There was a significant, curvilinear, inverse correlation between iron concentration by biopsy and liver T2* (r=0.93, P<0.0001). Inter-study cardiac reproducibility was 5.0%. As myocardial iron increased, there was a progressive decline in ejection fraction (r=0.61, P<0.001). All patients with ventricular dysfunction had a myocardial T2* of <20 ms. There was no significant correlation between myocardial T2* and the conventional parameters of iron status, serum ferritin and liver iron. Multivariate analysis of clinical parameters to predict the requirement for cardiac medication identified myocardial T2* as the most significant variable (odds ratio 0.79, P<0.002). Myocardial iron deposition can ...Continue Reading

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Jan 6, 2015·Professor Alister Hart

Citations

Apr 23, 2002·NMR in Biomedicine
Jun 14, 2008·Pediatric Cardiology·Firat KardelenAkif Yesilipek
Aug 22, 2007·Pediatric Radiology·Maria I Argyropoulou, Loukas Astrakas
Apr 6, 2005·Annals of Hematology·Ersi VoskaridouDimitris Loukopoulos
Nov 24, 2007·European Radiology·Declan P O'ReganStephan A Schmitz
Jan 22, 2013·European Radiology·Benjamin HenningerSchocke Michael
Sep 22, 2005·The International Journal of Cardiovascular Imaging·Mark A WestwoodDudley J Pennell
Jan 20, 2007·The International Journal of Cardiovascular Imaging·Sophie MavrogeniDennis V Cokkinos
Nov 26, 2009·The International Journal of Cardiovascular Imaging·Leo H B Baur
Mar 6, 2007·Current Gastroenterology Reports·James C Barton
Jun 20, 2008·Biological Trace Element Research·Utku N Yilmaz, R Guner
Sep 6, 2007·Indian Journal of Pediatrics·V P Choudhry, Rahul Naithani
Mar 31, 2009·Indian Journal of Pediatrics·M B Agarwal
Jul 3, 2008·International Journal of Hematology·Yutaka KohgoJunji Kato
Feb 19, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Michael Salerno
Feb 22, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ronny S JijiMichael Salerno
Jun 15, 2012·Insights Into Imaging·José María Alústiza EcheverríaJosé Ignacio Emparanza
Dec 21, 2010·Indian Pediatrics·Rashid MerchantBhavin Jankharia
Mar 2, 2005·Best Practice & Research. Clinical Haematology·A Victor Hoffbrand
Mar 2, 2005·Best Practice & Research. Clinical Haematology·Z Ioav CabantchikP Cianciulli
Apr 17, 2010·JACC. Cardiovascular Imaging·Darryl P LeongJoseph B Selvanayagam
Mar 1, 2005·Magnetic Resonance Imaging·E Mark HaackeAndre Obenaus
Jan 18, 2003·Lancet·Roland Fischer, Rainer Engelhardt
Mar 12, 2003·Journal of the American College of Cardiology·Christian M WackerWolfgang R Bauer
Sep 7, 2007·Nature Clinical Practice. Neurology·Susanne A SchneiderKailash P Bhatia
Feb 24, 2005·Current Opinion in Hematology·Melody J Cunningham, David G Nathan
Jun 15, 2006·Journal of Pediatric Hematology/oncology·Athanasios ChristoforidisMiranda Athanassiou-Metaxa
Aug 3, 2011·Cardiology in Review·Ronny S Jiji, Christopher M Kramer
Jan 26, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Antonio Cao, Renzo Galanello
Jun 23, 2009·Current Opinion in Pulmonary Medicine·Sat Sharma

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