Cardiovascular toxicity of decabrominated diphenyl ethers (BDE-209) and decabromodiphenyl ethane (DBDPE) in rats

Chemosphere
Li JingZhixiong Shi

Abstract

Recent reports indicated that decabrominated diphenyl ether (BDE-209) and decabromodiphenyl ethane (DBDPE) exist extensively in the environment. The toxicity of BDE-209 has been reported in quite a few studies, whereas the data of DBDPE are relatively rare. However, databases regarding cardiovascular toxicities of both BDE-209 and DBDPE are lacking. In this study, we investigated the vascular/cardiac trauma induced by DBDPE after oral exposure and compared the results with those of BDE-209 using rat model. Male rats were orally administered with corn oil containing DBDPE or BDE-209 (5, 50, 500 mg/kg/day) for 28 days, then oxidative stress, morphological and ultrastructural changes of the heart and abdominal aorta, levels of creatine kinase (CK) and lactate dehydrogenase (LDH), inflammatory cytokines, endothelin-1 (ET-1), and intercellular adhesion molecule-1 (ICAM-1) in the serum were monitored. Results showed that BDE-209 and DBDPE caused heart and abdominal aorta morphological and ultrastructural damage, serum CK and LDH elevation, and antioxidant enzyme activity changes. BDE-209 and DBDPE-induced inflammation was characterized by the upregulation of key inflammatory mediators, including interleukin-1beta (IL-1β), IL-6, IL-10...Continue Reading

Citations

Jul 24, 2020·Environmental Health Perspectives·Fabian A GrimmIvan Rusyn
Jul 23, 2020·Environmental Pollution·Naga Raju MaddelaMallavarapu Megharaj
Mar 17, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Feifei Shi, Xizeng Feng
May 1, 2021·International Journal of Molecular Sciences·Chander K NegiLuděk Bláha
Sep 16, 2020·Ecotoxicology and Environmental Safety·Feifei ShiXizeng Feng
May 20, 2021·Journal of Hazardous Materials·Katarzyna JędruchniewiczPatryk Oleszczuk
Apr 28, 2020·Ecotoxicology and Environmental Safety·Ming-Hong SunShao-Chen Sun

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