Care management of spasticity with botulinum toxin-A in patients with severe acquired brain injury: a 1-year follow-up prospective study

Brain Injury : [BI]
Alessandro ClemenziPaola Cicinelli

Abstract

To evaluate the efficacy and the safety of repeated botulinum toxin type A (BT-A) injections in patients with severe acquired brain injury (ABI) and to gain a better knowledge of possible clinical or demographic characteristics associated with a better rehabilitation outcome. Prospective study with a 1-year follow-up period. Twenty-one patients with spasticity due to severe ABI and no further improving with rehabilitation treatment and oral anti-spastic drugs. Repeated BT-A injections associated to a rehabilitation programme. Barthel Index (BI), Modified Ashworth Score (MAS) and VAS score for pain subjective perception were recorded. At the end of the follow-up study, MAS, BI and VAS significantly improved. Despite the number of BT-A injections, a shorter interval between severe ABI onset and first BT-A treatment correlated to a better BI improvement. None of the patients experienced adverse events attributable to BT-A. BT-A was effective and safe in the treatment of spasticity in severe ABI patients, with a better functional outcome in those subjects treated earlier after spasticity onset. The lack of correlation between clinical outcome and number of injections suggests, in addition to a direct inhibition at the neuromuscular...Continue Reading

References

Mar 1, 1975·Lancet·B Jennett, M Bond
Jan 1, 1979·International Rehabilitation Medicine·M J Rose
Apr 25, 1991·The New England Journal of Medicine·J Jankovic, M F Brin
Jan 1, 1988·International Disability Studies·C CollinV Horne
Apr 4, 2000·British Medical Bulletin·M P Barnes
Jan 10, 2002·Archives of Physical Medicine and Rehabilitation·Rita K Bode, Allen W Heinemann
Apr 17, 2002·Journal of Neurology·Marc RousseauxJérome Froger
Oct 4, 2002·American Journal of Physical Medicine & Rehabilitation·Areerat Suputtitada
Jul 13, 2004·The Journal of Head Trauma Rehabilitation·Ross ZafonteLisa Lombard
Jul 13, 2004·The Journal of Head Trauma Rehabilitation·Jay M MeythalerRobert C Brunner
Sep 18, 2004·Archives of Physical Medicine and Rehabilitation·Barbara J SingerJohn W Dunne
Apr 6, 2006·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Stephen Ashford, Lynne Turner-Stokes
Jun 21, 2006·Neurotoxicity Research·G Abbruzzese, A Berardelli
Aug 26, 2006·Southern Medical Journal·Mark Forrest Gordon, Rich Barron
Mar 17, 2007·Brain Injury : [BI]·Shawn MarshallMark Bayley
Dec 14, 2007·Journal of Rehabilitation Research and Development·William C Walker, Treven C Pickett
Apr 1, 2008·Archives of Physical Medicine and Rehabilitation·Hsin-Min LeeMaria Piotrkiewicz
Apr 26, 2008·American Journal of Physical Medicine & Rehabilitation·Alberto EsquenaziRoser Garreta
Sep 18, 2008·Neurorehabilitation and Neural Repair·Markus KoflerLeopold Saltuari
May 26, 2009·Developmental Neurorehabilitation·Emilie GuettardMathilde P Chevignard

❮ Previous
Next ❯

Citations

Sep 26, 2013·Neuroscience and Biobehavioral Reviews·Sergio BagnatoGiuseppe Galardi
Sep 17, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M A AkulovA A Tomskiy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Botulism

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Related Papers

Archives of Physical Medicine and Rehabilitation
Shanti GaneshTheresa Louise-Bender Pape
Archives of Physical Medicine and Rehabilitation
Marco SaràStefano Govoni
Practical Neurology
Ammar Kheder, Krishnan Padmakumari Sivaraman Nair
The New England Journal of Medicine
Susan Byrne, Orla Hardiman
© 2021 Meta ULC. All rights reserved