CaRES (Contrast Echocardiography Registry for Safety Surveillance): a prospective multicenter study to evaluate the safety of the ultrasound contrast agent definity in clinical practice

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Robert J WeissCaRES Investigators

Abstract

Definity (perflutren lipid microsphere) is an ultrasound contrast agent approved for use in patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border. This prospective, open-label, nonrandomized, multicenter, phase 4 surveillance registry study was conducted at 15 clinical sites in the United States and was designed to assess the risk for adverse cardiopulmonary events occurring during or within the initial 30 min after Definity administration in routine clinical practice. Patients with suboptimal baseline images were consecutively approached regarding study participation. Safety monitoring including vital sign measurements, continuous electrocardiographic monitoring, and continuous oxygen saturation was initiated at baseline before Definity administration and then at regular intervals for 30 min after Definity injection. Patients were assessed for adverse events at 30 min after Definity administration and then contacted by telephone at 24 ± 4 hours to record any subsequent adverse events. A total of 1,060 patients were enrolled at 15 clinical sites. Of these, 1,053 (99.3%) received at least one dose of Definity and completed the st...Continue Reading

References

Sep 12, 2007·Circulation·Andrew J EinsteinMilena J Henzlova
May 8, 2008·JAMA : the Journal of the American Medical Association·Charles A Herzog
Oct 14, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Kevin WeiRoberto M Lang
Oct 23, 2008·The American Journal of Cardiology·Ruvin S GabrielEllen Mayer Sabik
Feb 25, 2009·Expert Opinion on Drug Safety·Michael L MainPaul A Grayburn
Jan 13, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·George A Beller

❮ Previous
Next ❯

Citations

Mar 22, 2014·The International Journal of Cardiovascular Imaging·Matthew S Glassy, Elliott M Groves
Jun 16, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Kevin WeiAnthony DeMaria
Dec 22, 2015·Expert Review of Cardiovascular Therapy·Anastasia VamvakidouRoxy Senior
Sep 21, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Alda HuqiHarald Becher
Sep 18, 2013·The American Journal of Cardiology·Michael L MainAnthony N DeMaria
Jan 22, 2013·The Canadian Journal of Cardiology·Robin DucasKwan Leung Chan
Aug 6, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Manfred HaubenVincenza Snow
Jan 13, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Reshani H PereraAgata A Exner
Apr 12, 2016·Expert Opinion on Biological Therapy·Hao H ChenHoward Leong-Poi
Apr 25, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Anthony Putrino, David G Platts
Mar 31, 2015·Progress in Cardiovascular Diseases·Faraz Pathan, Thomas H Marwick
Jul 3, 2013·The American Journal of Cardiology·Jeremy M ParkerSteven B Feinstein
Apr 6, 2017·Circulation. Cardiovascular Imaging·Preetham R Muskula, Michael L Main
Dec 23, 2015·Echo Research and Practice·Andrew W AppisSteven B Feinstein
Apr 21, 2021·BMJ Case Reports·Tanveer MirAlward Abdo
Aug 8, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Tiffany M WilliamsJacques Neelankavil

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antipsychotic-Induced Weight Gain

Antipsychotic-induced weight gain (aiwg) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. Here are the latest discoveries pertaining to AIWG.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

© 2021 Meta ULC. All rights reserved