PMID: 8983467Aug 1, 1996Paper

Carinal and tubular airway particle concentrations in the large airways of non-smokers in the general population: evidence for high particle concentration at airway carinas

Occupational and Environmental Medicine
A Churg, S Vedal

Abstract

To evaluate the extent to which human airway carinas accumulate ambient atmospheric particles, a newly developed technique was used to micro-dissect and analyse particle concentration in tubular segments and carinas of the large airways of 10 necropsy lungs from non-smokers from the general population of Vancouver. Ratios of the particle concentrations on the carinas to the tubular segment immediately preceding it were measured with analytical electron microscopy for the mainstem bronchus, upper and lower lobe bronchi, and four different segmental or subsegmental bronchi--that is, Weibel generations 1 to about 5. A total of 119 carinal-tubular pairs was evaluated. Over all cases, both carinal and tubular particle concentrations increased with increasing airway generation; the median ratio of carinal to tubular particle concentration was 9:1 and did not show any trend with airway generation. The ratio was > 5 in 71% of carinal-tubular pairs, > 10 in 42% of pairs, > 20 in 31% of pairs, and > 100 in 9% of pairs. Some subjects showed a notable tendency to high ratios, with many ratios > 100, and other subjects had a tendency toward low ratios. The predominant mineral species in both carinas and tubular airway segments was crystalli...Continue Reading

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Aug 6, 2003·Free Radical Biology & Medicine·Florence TaoLester Kobzik
Oct 14, 2010·Inhalation Toxicology·Robert F PhalenMichael J Oldham
Mar 27, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hongchen WangLudovic de Rochefort
Mar 14, 2008·Computers in Biology and Medicine·Arpád Farkas, Imre Balásházy
Jan 14, 2009·Radiation Research·István SzokeWerner Hofmann
Aug 16, 2015·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Frantisek LizalMiroslav Jicha
Apr 1, 2004·International Journal of Cancer. Journal International Du Cancer·Paul J A BormCatrin Albrecht
Oct 29, 2002·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·I BalásházyI Szoke
Jun 4, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Robert F PhalenRonald K Wolff
Jan 13, 2005·Radiation Protection Dosimetry·H FakirI Aubineau-Lanièce
Sep 9, 2004·The Journal of Small Animal Practice·M M R E NizaC L Vilela
Jul 30, 2011·Metallomics : Integrated Biometal Science·R Steve Pappas
Jul 31, 2019·Journal of Occupational and Environmental Hygiene·Karin LovénAnders Gudmundsson
Oct 7, 2019·Radiation and Environmental Biophysics·Péter FüriImre Balásházy
Jun 12, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samantha C FaberShaun D McCullough
Jan 21, 2003·Journal of Applied Physiology·Imre BalashazyThomas Heistracher
Sep 15, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Margaux CochardYann Landkocz
Apr 7, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Robert F PhalenAndre E Nel

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