Caring for children with NAFLD and navigating their care into adulthood

Nature Reviews. Gastroenterology & Hepatology
Ali A MencinJoel E Lavine

Abstract

NAFLD is the most common chronic liver disease in children and adults, with its prevalence closely associated with obesity and other features of the metabolic syndrome. As young adults with NAFLD transition from the paediatric care environment to adult services, establishing a coordinated model of transition to ensure ongoing and appropriate care is critical. Enabling a smooth transfer begins with an understanding of the key differences between paediatric and adult NAFLD as well as the psychosocial factors that affect older adolescents. This Review summarizes the literature on paediatric NAFLD from the past two decades with a focus on the differences in epidemiology, pathology, pathophysiology and treatment that are relevant to clinicians who transition paediatric patients to adult care. An integrated model, which employs a team of adult and paediatric providers who can address the psychosocial, cognitive and logistical challenges of transition, provides the best opportunity for a seamless and coordinated transfer to adult care.

References

Sep 26, 1997·The New England Journal of Medicine·R C WhitakerW H Dietz
Nov 5, 1999·JAMA : the Journal of the American Medical Association·A MustW H Dietz
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Jungermann, T Kietzmann
Feb 19, 2000·Cleveland Clinic Journal of Medicine·S Saadeh, Z M Younossi
Aug 29, 2002·The American Journal of Clinical Nutrition·Shumei Sun GuoAlex F Roche
Apr 25, 2003·The New England Journal of Medicine·Eugenia E CalleMichael J Thun
Jun 18, 2003·The American Journal of Gastroenterology·Jeanne M ClarkAnna Mae Diehl
Feb 10, 2004·Journal of American College Health : J of ACH·Terry T K HuangHarsohena Kaur
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Feb 4, 2005·The Journal of Clinical Investigation·Ramón Bataller, David A Brenner
Mar 9, 2005·Archives of General Psychiatry·Wendy S Slutske
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jul 8, 2005·Journal of Clinical Gastroenterology·Mark FishbeinW Ross Stevens
Aug 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey B SchwimmerJoel E Lavine
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtStergios Kechagias
Oct 4, 2006·Pediatrics·Jeffrey B SchwimmerCynthia Behling
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Mar 22, 2008·Pediatric Research·Lucia PacificoClaudio Chiesa
May 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Winston DunnJeffrey B Schwimmer
May 20, 2008·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Jennifer A BaileyKevin P Haggerty
Jun 10, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Valerio NobiliPaul Angulo
Jul 9, 2008·Journal of Pediatric Gastroenterology and Nutrition·Fatih DemircioğluAlparslan Tuncel Sedat
Aug 7, 2008·Journal of Hepatology·Janus P OngZobair M Younossi
Aug 8, 2008·The American Journal of Gastroenterology·Winston DunnJeffrey B Schwimmer
Sep 5, 2008·The Journal of Clinical Investigation·Simon SchenkJerrold M Olefsky
Sep 19, 2008·JAMA : the Journal of the American Medical Association·Iain A LangDavid Melzer
Nov 18, 2008·Gastroenterology·Heather M PattonUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Dec 4, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nila RafiqZobair M Younossi
Dec 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Philip J Scarpace, Yi Zhang
Feb 12, 2009·Gastroenterology·Jeffrey B SchwimmerClaude B Sirlin
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sean F AltekruseMarsha E Reichman
May 30, 2009·Journal of Gastroenterology and Hepatology·Anuradha S DassanayakeH Janaka de Silva
Jun 9, 2009·Journal of Hepatology·Curtis K ArgoStephen H Caldwell
Jul 29, 2009·Health Affairs·Eric A FinkelsteinWilliam Dietz
Jul 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christine Carter-KentAriel E Feldstein
Aug 22, 2009·Digestive Diseases and Sciences·Jae Sung KoJeong Kee Seo
Oct 15, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kittichai PromratRena R Wing
Jan 22, 2010·Current Opinion in Pediatrics·Maida P GalvezIrene H Yen

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Citations

Mar 24, 2018·Journal of Pediatric Gastroenterology and Nutrition·Pietro VajroHenkjan J Verkade
Dec 1, 2017·BMC Gastroenterology·Shaman RajindrajithH Janaka de Silva
Jul 30, 2021·Journal of Pediatric Gastroenterology and Nutrition·Sanita L LeyUNKNOWN Teen View Study Group and in collaboration with the Teen-LABS Consortium

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