CARM1 promotes adipocyte differentiation by coactivating PPARgamma

EMBO Reports
Neelu YadavMark T Bedford

Abstract

The coactivator-associated arginine methyltransferase 1 (CARM1) is recruited to gene promoters by many transcription factors. To identify new pathways that use CARM1, we carried out a comprehensive transcriptome analysis of CARM1-knockout embryos. By using complementary DNA microarrays and serial analysis of gene expression, we identified various genes involved in lipid metabolism that were underrepresented in CARM1-knockout embryos, indicating an important role for this coactivator in adipose tissue biology. We also observed that the amount of brown fat in CARM1-knockout embryos is reduced. Furthermore, cells lacking CARM1 have a severely curtailed potential to differentiate into mature adipocytes. Reporter experiments and chromatin immunoprecipitation analysis show that CARM1 regulates these processes by acting as a coactivator for peroxisome proliferator-activated receptor gamma (PPARgamma). Together, these results show that CARM1 promotes adipocyte differentiation by coactivating PPARgamma-mediated transcription and thus might be important in energy balance.

References

May 15, 1994·Genes & Development·P TontonozB M Spiegelman
Oct 20, 1998·Thyroid : Official Journal of the American Thyroid Association·B A CunninghamW B Kinlaw
Jun 26, 1999·Science·D ChenM R Stallcup
Aug 18, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·K M WatersK W Gaido
May 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Neelu YadavMark T Bedford
Sep 8, 2004·Trends in Molecular Medicine·Sheng-Cai Lin, Peng Li
Oct 9, 2004·The Journal of Biological Chemistry·Meenakshisundaram AnanthanarayananMartin J Walsh
Feb 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Young-Ho LeeMichael R Stallcup
May 4, 2005·Molecular Cell·Mark T Bedford, Stéphane Richard
Dec 7, 2005·The Journal of Biological Chemistry·Anja Krones-HerzigStephan Herzig
May 30, 2006·Biochimica Et Biophysica Acta·Richard K Porter
Nov 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jean-Francois LouetBert W O'Malley
Dec 2, 2006·Nature Reviews. Molecular Cell Biology·Evan D Rosen, Ormond A MacDougald

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Citations

Aug 6, 2013·Nature Communications·Katsunori FujikiMasayuki Murata
Dec 14, 2012·Nature Reviews. Cancer·Yanzhong Yang, Mark T Bedford
Nov 10, 2009·The Journal of Biological Chemistry·Daehoon KimMark T Bedford
Oct 12, 2010·Molecular & Cellular Proteomics : MCP·Tanya C Petrossian, Steven G Clarke
Sep 4, 2010·PPAR Research·Navin ViswakarmaJanardan K Reddy
May 2, 2009·Molecular Endocrinology·Susan C Wu, Yi Zhang
May 25, 2012·Expert Opinion on Therapeutic Targets·Boksik Cha, Eek-Hoon Jho
Feb 6, 2016·Biochemistry·Suzanne L JacquesThomas V Riera
Jan 9, 2016·Biochemistry·Renee DesJarlais, Peter J Tummino
Nov 10, 2015·ACS Chemical Biology·P Ann Boriack-SjodinRobert A Copeland
Oct 25, 2014·European Journal of Nutrition·Isabella ZanellaDiego Di Lorenzo
Jun 6, 2008·PPAR Research·Moray J CampbellH Phillip Koeffler
Jul 2, 2010·Organogenesis·Melina M MusriMarcelina Párrizas
Feb 18, 2015·Mutagenesis·Alan MorettinJocelyn Côté
Jun 3, 2016·Nature Reviews. Molecular Cell Biology·Takeshi InagakiShingo Kajimura
Jan 20, 2009·Molecular Cell·Mark T Bedford, Steven G Clarke
May 22, 2018·Expert Opinion on Therapeutic Targets·Emily SmithRobert A Baiocchi
Sep 6, 2018·International Journal of Molecular Sciences·Jelena KrsticAndreas Prokesch
Nov 17, 2016·Molecular and Cellular Biology·Roméo Sébastien BlancStéphane Richard
Nov 16, 2010·FEBS Letters·Alessandra Di Lorenzo, Mark T Bedford
May 25, 2011·FEBS Letters·Shigeki Sugii, Ronald M Evans
Jan 7, 2015·Endocrinology and Metabolism·Hye Sook HanSeung Hoi Koo
Jan 1, 2013·F1000Research·Yu-Jie HuAnthony N Imbalzano
Jan 6, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Eun-Seo LeeNathaniel S Hwang
Jan 30, 2020·Natural Product Reports·Levi W EvansBradley S Ferguson
Aug 7, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Felix Grün

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