CARMA1 is required for Akt-mediated NF-kappaB activation in T cells

Molecular and Cellular Biology
Preeti NarayanLawrence P Kane

Abstract

Many details of the generic pathway for induction of NF-kappaB have been delineated, but it is still not clear how multiple, diverse receptor systems are able to converge on this evolutionarily conserved family of transcription factors. Recent studies have shown that the CARMA1, Bcl10, and MALT1 proteins are critical for coupling the common elements of the NF-kappaB pathway to the T-cell receptor (TCR) and CD28. We previously demonstrated a role for the serine/threonine kinase Akt in CD28-mediated NF-kappaB induction. Using a CARMA1-deficient T-cell line, we have now found that the CARMA complex is required for induction of NF-kappaB by Akt, in cooperation with protein kinase C activation. Furthermore, using a novel selective inhibitor of Akt, we confirm that Akt plays a modulatory role in NF-kappaB induction by the TCR and CD28. Finally, we provide evidence for a physical and functional interaction between Akt and CARMA and for Akt-dependent phosphorylation of Bcl10. Therefore, in T cells, Akt impinges upon NF-kappaB signaling through at least two separate mechanisms.

References

Jun 9, 1999·Current Biology : CB·L P KaneA Weiss
Sep 15, 1999·Nature·J A Romashkova, S S Makarov
Jun 3, 2000·Annual Review of Immunology·M Karin, Y Ben-Neriah
Mar 8, 2002·Cellular Signalling·Karleen M Nicholson, Neil G Anderson
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Jul 23, 2002·Trends in Immunology·Lawrence P KaneArthur Weiss
Jul 26, 2002·Molecular and Cellular Biology·Lawrence P KaneArthur Weiss
Aug 3, 2002·Nature Immunology·Donghai WangXin Lin
Oct 3, 2002·Nature Reviews. Immunology·Qiutang Li, Inder M Verma
Feb 26, 2003·The Journal of Biological Chemistry·Tianyun Jiang, Yun Qiu
Apr 3, 2003·Immunological Reviews·Lawrence P Kane, Arthur Weiss
Jun 24, 2003·Immunity·Hiromitsu HaraJosef M Penninger
Nov 26, 2003·The Journal of Biological Chemistry·Astrid A Ruefli-BrasseVishva M Dixit
Dec 26, 2003·Nature·Honglin ZhouVishva M Dixit
Mar 3, 2004·Molecular and Cellular Biology·Michael G TomlinsonArthur Weiss
Mar 17, 2004·Biochimica Et Biophysica Acta·Masahito HanadaBrian A Hemmings
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lawrence P KaneArthur Weiss
May 4, 2004·Nature Reviews. Immunology·Margot Thome
May 4, 2004·Nature Reviews. Molecular Cell Biology·Lin-Feng Chen, Warner C Greene
Jun 9, 2004·The Journal of Biological Chemistry·Romania StiloPasquale Vito
Jul 29, 2004·The Journal of Experimental Medicine·Marina S VivarelliRaif S Geha
Nov 3, 2004·The Journal of Experimental Medicine·Hiromitsu HaraJosef M Penninger
Nov 13, 2004·Immunity·Jennifer L CannonsPamela L Schwartzberg
Jan 25, 2005·Bioorganic & Medicinal Chemistry Letters·Craig W LindsleyMark E Duggan
Feb 3, 2005·Bioorganic & Medicinal Chemistry Letters·Zhijian ZhaoCraig W Lindsley
Apr 2, 2005·Science·Nicolai S C van Oers, Zhijian J Chen
Apr 28, 2005·Current Topics in Medicinal Chemistry·Stanley F BarnettCraig W Lindsley
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Russell G JonesPamela S Ohashi
Sep 17, 2005·Molecular and Cellular Biology·Kris A SteinbrecherAlbert S Baldwin

❮ Previous
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Citations

Jul 1, 2011·Immunologic Research·Jing ChengLawrence P Kane
Dec 29, 2010·Cell Research·Marzenna Blonska, Xin Lin
Oct 26, 2006·Nature Reviews. Immunology·David J RawlingsMiguel E Moreno-García
Aug 25, 2011·The Journal of Biological Chemistry·Jing ChengLawrence P Kane
Aug 6, 2010·Cold Spring Harbor Perspectives in Biology·Margot ThomeStephan Hailfinger
Jan 30, 2008·Molecular and Cellular Biology·Guilin QiaoJian Zhang
Aug 3, 2011·Molecular and Cellular Biology·Judong LeeLawrence P Kane
Jan 10, 2009·Annual Review of Immunology·Jennifer E Smith-GarvinMartha S Jordan
May 29, 2010·BMC Immunology·Hazem KhalafPer-Erik Olsson
Jun 13, 2013·Critical Reviews in Immunology·Marly I RocheBenjamin D Medoff
Dec 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Atsushi KanedaAndrew P Feinberg
Nov 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefanie KlemmJürgen Ruland
May 12, 2010·Seminars in Immunopathology·Magdalena Paolino, Josef M Penninger
Nov 21, 2012·Expert Opinion on Emerging Drugs·Pearlie K Epling-BurnetteAlan F List
Sep 18, 2012·The International Journal of Biochemistry & Cell Biology·Arun KannanAvery August
Oct 21, 2015·Seminars in Cell & Developmental Biology·Charles W Wolgemuth
Sep 2, 2008·Immunological Reviews·Xiao-Ping ZhongChi-Keung Wan
Mar 1, 2012·The Biochemical Journal·Lomon So, David A Fruman
Mar 24, 2017·Environmental Science and Pollution Research International·Priyanka Prasad, Dona Sinha
Nov 14, 2006·Immunity·Jan Schulze-Luehrmann, Sankar Ghosh
May 1, 2007·Trends in Immunology·Margot Thome, Robert Weil
Mar 28, 2013·International Journal of Molecular Sciences·Rohan P Joshi, Gary A Koretzky
Apr 18, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesco MarangoniThorsten R Mempel
Dec 20, 2014·Journal of Leukocyte Biology·Weishan Huang, Avery August
Mar 8, 2014·Immune Network·Sang-Heon ParkSung-Gyoo Park
Mar 18, 2009·Immunological Reviews·Marzenna Blonska, Xin Lin
Jan 30, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stalin ChellappaKjetil Taskén
Dec 2, 2009·European Journal of Immunology·Elissa K DeenickPamela S Ohashi
Feb 13, 2020·Biochemical Society Transactions·Jessica P ElmoreAvery August
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianxun SongMichael Croft
Aug 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antonio J PagánMarc K Jenkins
Jan 1, 2012·F1000Research·Jean LinLawrence P Kane
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiromitsu HaraTakashi Saito
Dec 16, 2010·The EMBO Journal·Andrea C EitelhuberDaniel Krappmann
Jun 9, 2020·Frontiers in Immunology·Nayan D Bhattacharyya, Carl G Feng
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anjali J de SouzaLawrence P Kane
Aug 14, 2019·Immunological Reviews·Silvia PreitePamela L Schwartzberg

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