CARMA3 Is a Critical Mediator of G Protein-Coupled Receptor and Receptor Tyrosine Kinase-Driven Solid Tumor Pathogenesis

Frontiers in Immunology
J Randall McAuleyLinda M McAllister-Lucas

Abstract

The CARMA-Bcl10-MALT1 (CBM) signalosome is an intracellular protein complex composed of a CARMA scaffolding protein, the Bcl10 linker protein, and the MALT1 protease. This complex was first recognized because the genes encoding its components are targeted by mutation and chromosomal translocation in lymphoid malignancy. We now know that the CBM signalosome plays a critical role in normal lymphocyte function by mediating antigen receptor-dependent activation of the pro-inflammatory, pro-survival NF-κB transcription factor, and that deregulation of this signaling complex promotes B-cell lymphomagenesis. More recently, we and others have demonstrated that a CBM signalosome also operates in cells outside of the immune system, including in several solid tumors. While CARMA1 (also referred to as CARD11) is expressed primarily within lymphoid tissues, the related scaffolding protein, CARMA3 (CARD10), is more widely expressed and participates in a CARMA3-containing CBM complex in a variety of cell types. The CARMA3-containing CBM complex operates downstream of specific G protein-coupled receptors (GPCRs) and/or growth factor receptor tyrosine kinases (RTKs). Since inappropriate expression and activation of GPCRs and/or RTKs underlies t...Continue Reading

References

May 1, 1997·Trends in Biochemical Sciences·K HofmannJ Tschopp
Sep 15, 1999·Nature·J A Romashkova, S S Makarov
Aug 30, 2000·Histology and Histopathology·R K Singh, M L Varney
Jun 2, 2001·The Journal of Biological Chemistry·L M McAllister-LucasG Núñez
Aug 3, 2002·Nature Immunology·Donghai WangXin Lin
Dec 26, 2003·Nature·Honglin ZhouVishva M Dixit
Jan 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Brian C SchaeferPhilippa Marrack
Mar 5, 2004·British Journal of Cancer·L Juillerat-JeanneretJ-M Gasc
Jun 9, 2004·The Journal of Biological Chemistry·Romania StiloPasquale Vito
Sep 30, 2004·Technology in Cancer Research & Treatment·S LehrerR G Stock
Oct 7, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shailesh SinghJames W Lillard
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takayasu SuganumaFumitaka Kikkawa
Jul 30, 2005·Journal of Cellular Biochemistry·Kwanchanit TantivejkulKenneth J Pienta
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·S R Coughlin
Dec 17, 2005·Immunity·Karen SommerDavid J Rawlings
Feb 24, 2006·Molecular Biology of the Cell·Jeremy S RossmanBrian C Schaefer
Nov 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefanie KlemmJürgen Ruland
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Linda M McAllister-LucasPeter C Lucas
Dec 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Donghai WangXin Lin
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel RuedaMargot Thome
Apr 18, 2007·Genes & Development·Brian C GrabinerXin Lin
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christoph RöckenMatthias P A Ebert
Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·J T B CrawleyD A Lane
Oct 20, 2007·The EMBO Journal·Andrea OeckinghausDaniel Krappmann
Mar 8, 2008·Science·Georg LenzLouis M Staudt
Mar 19, 2008·Seminars in Perinatology·Brandy L FrostMichael S Caplan

❮ Previous
Next ❯

Citations

Apr 8, 2021·Oncogenesis·Laura IsraëlFrédéric Bornancin
May 8, 2019·The Journal of Allergy and Clinical Immunology·Henry Y LuStuart E Turvey

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

© 2022 Meta ULC. All rights reserved