Carmofur-induced organic mental disorders.

The Japanese Journal of Psychiatry and Neurology
T SuzukiM Hori

Abstract

Organic mental disorder was observed in a 29-year-old female in the prognostic period after the onset of carmofur-induced leukoencephalopathy. Symptoms such as euphoria, emotional lability and puerile attitude noted in the patient were diagnosed as organic personality syndrome according to the criteria defined in the DSM-III-R. It is referred to as a frontal lobe syndrome. Brain CT revealed a periventricular low density area in the frontal white matter and moderate dilatation of the lateral ventricles especially at the bilateral anterior horns. Consequently, carmofur-induced leukoencephalopathy may uncommonly result in organic personality syndrome in the residual state. It may be attributed to the structural damage to the frontal lobe.

References

Jun 1, 1989·Asia-Oceania Journal of Obstetrics and Gynaecology·T YamadaY Masui
Aug 1, 1987·Journal of Neurology·S KuzuharaY Toyokura

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