Carnitine in bacterial physiology and metabolism

Microbiology
Jamie A Meadows, Matthew J Wargo

Abstract

Carnitine is a quaternary amine compound found at high concentration in animal tissues, particularly muscle, and is most well studied for its contribution to fatty acid transport into mitochondria. In bacteria, carnitine is an important osmoprotectant, and can also enhance thermotolerance, cryotolerance and barotolerance. Carnitine can be transported into the cell or acquired from metabolic precursors, where it can serve directly as a compatible solute for stress protection or be metabolized through one of a few distinct pathways as a nutrient source. In this review, we summarize what is known about carnitine physiology and metabolism in bacteria. In particular, recent advances in the aerobic and anaerobic metabolic pathways as well as the use of carnitine as an electron acceptor have addressed some long-standing questions in the field.

References

Jun 1, 1979·Journal of General Microbiology·A R StrømH Larsen
Aug 1, 1975·Archives of Biochemistry and Biophysics·M Klagsbrun, A V Furano
Jan 30, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R Jaenicke
Feb 1, 1991·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P MarcianiG Esposito
Jan 1, 1990·Journal of Basic Microbiology·H JungH P Kleber
Jan 1, 1988·Annual Review of Biochemistry·L L Bieber
Jan 1, 1988·Advances in Protein Chemistry·P L Privalov, S J Gill
Jan 1, 1987·Journal of Basic Microbiology·K JungH P Kleber
Nov 1, 1986·Journal of Bacteriology·S Nobile, J Deshusses
Jan 1, 1985·Annual Review of Microbiology·E L Barrett, H S Kwan
Feb 15, 1986·Archives of Biochemistry and Biophysics·A S RudolphL M Crowe
Oct 1, 1972·Journal of General Microbiology·A D Brown, J R Simpson
May 26, 1966·Biochimica Et Biophysica Acta·T UnemotoM Hayashi
Oct 27, 1970·Biochemistry·G LindstedtM Tofft
Jun 24, 1968·Biochimica Et Biophysica Acta·G LindstedtM Tofft
Jul 11, 1967·Biochimica Et Biophysica Acta·H AurichW D Schöpp
Oct 1, 1983·Physiological Reviews·J Bremer
Jan 1, 1995·Journal of Basic Microbiology·K EichlerM A Mandrand-Berthelot
Jan 1, 1994·Applied Microbiology and Biotechnology·U Joeres, M R Kula
Sep 1, 1994·Molecular Microbiology·K EichlerM A Mandrand-Berthelot
May 1, 1993·European Journal of Biochemistry·U RüetschiS Lindstedt
Jun 4, 1996·Biochimica Et Biophysica Acta·H HanschmannH P Kleber
Feb 1, 1997·FEMS Microbiology Letters·H P Kleber
Aug 26, 1998·Annual Review of Nutrition·C J Rebouche, H Seim
Oct 10, 1998·Research in Microbiology·M JebbarS Bonnassie
Nov 27, 1998·Journal of Applied Microbiology·M R CastellarJ L Iborra
Jan 1, 1999·Journal of Applied Microbiology·A VerheulT Abee
Apr 21, 1999·Biochimica Et Biophysica Acta·A PreusserH P Kleber
May 26, 1999·FEMS Microbiology Letters·T ElssnerH P Kleber
Jul 28, 1999·Applied Microbiology and Biotechnology·J M ObónJ L Iborra
Mar 23, 2000·Letters in Applied Microbiology·D O Bayles, B J Wilkinson

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Citations

Apr 30, 2016·Bioscience, Biotechnology, and Biochemistry·Hiroshi FujimitsuNobuhiro Mori
Jul 20, 2016·The Science of the Total Environment·Deirdre GleesonMatthias Leopold
Oct 21, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Diede FennemaElizabeth A Shephard
Jul 14, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Arthur L Beaudet
Aug 10, 2018·PLoS Computational Biology·Patrick H BradleyKatherine S Pollard
Oct 16, 2018·MicrobiologyOpen·Jennifer BreischBeate Averhoff
Jan 24, 2019·Journal of Bacteriology·Pascal BazireAlain Perret
May 16, 2019·Environmental Microbiology·Stephen E Noell, Stephen J Giovannoni
Feb 15, 2019·Clinical Epigenetics·Yuko KurushimaJordana T Bell
Jul 8, 2020·Applied and Environmental Microbiology·Ting YangWei-Dong Lu
Jul 29, 2020·Nutrition Research Reviews·Saba NaghipourJohn P Headrick
Sep 18, 2020·Pediatric Research·Madeleine ErnstArieh S Cohen
Sep 29, 2020·Nature Communications·Ashkaan K Fahimipour, Thilo Gross
May 31, 2019·Nature·Jason Lloyd-PriceCurtis Huttenhower
Mar 31, 2018·International Journal of Molecular Sciences·Abdallah GhonimyQiuju Wang
Jun 6, 2020·Frontiers in Microbiology·Tetyana Milojevic, Wolfram Weckwerth
Jan 21, 2021·Metabolites·Santosh LamichhaneMatej Orešič
Jan 27, 2020·The Science of the Total Environment·Xihao DuHaidong Kan
Feb 23, 2021·Computational and Structural Biotechnology Journal·Gwendolyn J Gregory, E Fidelma Boyd
May 4, 2021·Frontiers in Bioengineering and Biotechnology·Pierre KuglerVolker F Wendisch
Aug 17, 2019·Microbiology Spectrum·John-Demian SauerMary X D O'Riordan
Jun 5, 2021·BMC Microbiology·Jinhee KimRonaldo P Ferraris

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