Carnitine prevents cyclic GMP-induced inhibition of peroxisomal enzyme activities

Cell Biochemistry and Function
Gursev S DhaunsiAllie Moosa

Abstract

Peroxisomes, also termed as microbodies, are now known to carry out several specialized metabolic activities that are vital to cellular function. A defect in peroxisomal function leads to development of a fatal human disease, and a number of peroxisomal disorders are now linked to inherited peroxisomal enzyme abnormalities. Peroxisomal enzyme activities are also altered during pathophysiological conditions through various endogenously produced bio-molecules such as nitric oxide (NO). NO produced by cytokines or NO-donors is known to modulate peroxisomal functions, and these effects of NO are mediated through cGMP. We are reporting for the first time that L-carnitine (1-5 mm) prevents cGMP-mediated impairment of peroxisomal enzyme activities. Cyclic GMP (250-1000 muM) significantly inhibited (p < 0.01) the specific activities of catalase, acyl CoA oxidase and dihydroxyacetone-phosphate acyltransferase (DHAPATase) in human dermal fibroblasts, and treatment of cells with 1-5 mM of carnitine significantly (p < 0.001) reduced the inhibitory effects of cGMP on peroxisomal enzyme activities. These findings suggest that carnitine, previously thought to participate only in fatty acid oxidation, may in fact be regulating other cellular e...Continue Reading

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·W P ArnoldF Murad
Jan 1, 1992·Annual Review of Biochemistry·H van den BoschJ M Tager
May 15, 1992·Archives of Biochemistry and Biophysics·S GulatiI Singh
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Jan 1, 1982·Annals of the New York Academy of Sciences·A K Hajra, J E Bishop
Jun 1, 1993·American Journal of Diseases of Children·F R BrownI Singh
Jun 29, 1994·Molecular and Cellular Biochemistry·G S DhaunsiI Singh
Oct 20, 1993·Biochimica Et Biophysica Acta·S GulatiI Singh
Jan 1, 1993·Biochimie·G P Mannaerts, P P Van Veldhoven
Jan 1, 1995·Journal of Inherited Metabolic Disease·P P Van Veldhoven
Apr 2, 1999·Early Human Development·J ArenasY Campos
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A ContrerasA K Singh

❮ Previous
Next ❯

Citations

Nov 9, 1995·Biochemical Pharmacology·H Coste, P Grondin
Oct 1, 1995·General Pharmacology·S UlkerS Koşay
Jan 1, 1989·Free Radical Biology & Medicine·P D Cherry, M S Wolin
Oct 30, 1990·European Journal of Pharmacology·K IvanovaR Gerzer
May 29, 2003·Journal of Insect Physiology·David B. Morton, P Jeanette Simpson
Jul 31, 1998·Thrombosis Research·B Brüne, K Hanstein
Mar 20, 1998·Comparative Biochemistry and Physiology. Part A, Physiology·S P Brooks, K B Storey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.