PMID: 2499353Jun 8, 1989Paper

Carnitine transport and exogenous palmitate oxidation in chronically volume-overloaded rat hearts

Biochimica Et Biophysica Acta
Z El Alaoui-Talibi, J Moravec

Abstract

L-Carnitine transport and free fatty acid oxidation have been studied in hearts of rats with 3-month-old aorto-caval fistula. For carnitine transport experiments, the hearts were perfused via the ascending aorta with a bicarbonate buffer containing 11 mM glucose and variable concentrations L-[14C]carnitine (10-200 microM). In some experiments, the active component of carnitine transport was suppressed by the adjunction of 0.05 mM mersalyl acid. The subtraction of passive from total transport allowed reconstruction of the saturation curves of the carrier-mediated transport of L-carnitine. Our data suggest that at a physiological carnitine concentration (50 microM), the rate of [14C]carnitine accumulation was significantly depressed in mechanically overloaded hearts. In addition, according to Lineweaver-Burk analysis, the affinity of the membrane carrier for L-carnitine was considerably diminished (Km carnitine 125 instead of 83 microM, Vmax unchanged). The above alterations of L-carnitine transport did not result from a decrease of the transmembrane gradient of sodium, since the intracellular Na+ content of the hypertrophied hearts was quite similar to that of control hearts. The ability of atrially perfused, working hearts to o...Continue Reading

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Citations

Jun 1, 1993·Cardiovascular Drugs and Therapy·Z el Alaoui-TalibiJ Moravec
Jan 21, 2010·Physiological Reviews·Gary D LopaschukWilliam C Stanley
Feb 19, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·M TrumJ Mustroph
Jun 3, 2021·International Journal of Molecular Sciences·Dianne M Perez

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