Carnosic acid (CA) prevents lipid accumulation in hepatocytes through the EGFR/MAPK pathway.

Journal of Gastroenterology
Ting WangKazuyuki Suzuki

Abstract

Carnosic acid (CA), found in rosemary, has been reported to have antioxidant and anti-adipogenic properties. We recently demonstrated that CA protects against steatosis in ob/ob mice. In the present report, we investigated the molecular mechanism by which CA inhibits lipids accumulation both in vivo and in vitro. In the in vivo study, ob/ob mice were fed a standard chow diet with or without CA for 5 weeks, then their hepatocyte lipid accumulation was determined. The serum concentrations of cytokines, the levels of lipid regulatory mediators, and the hepatic metabolic and signaling molecules were also evaluated. In the in vitro study, HepG2 cells were used to further clarify the effects of CA on cellular lipid accumulation and to confirm the signaling pathways involved in these effects. CA significantly reduced hepatocyte lipid accumulation. This effect was associated with repressed levels of hepatic PPARγ, reduced expression of inflammatory cytokines such as IL-1β, IL-12, IL-17, IFN-γ, MCP-1, and MIP-1β, and increased ATP, acetyl CoA, NAD(P)(+), and NAD(P)H. Other signaling molecules, such as EGFR, MAPK, AMPK, and ACC, which regulate lipid metabolism, were activated in mice fed the CA diet. CA inhibited palmitate-induced cellul...Continue Reading

References

Feb 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·O I AruomaJ Löligers
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A A NanjiG L Su
Apr 20, 2000·The Journal of Clinical Investigation·I A LeclercqG R Robertson
Mar 6, 2003·The Journal of Clinical Investigation·Kimihiko MatsusueFrank J Gonzalez
Jul 9, 2004·Journal of Leukocyte Biology·Britta SiegmundGiamila Fantuzzi
Dec 14, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C Lelliott, A J Vidal-Puig
Mar 1, 2005·Biochimie·F BostB Binétruy
Jan 6, 2006·International Journal of Cancer. Journal International Du Cancer·Hagar SharabaniMichael Danilenko
Jan 27, 2006·International Journal of Experimental Pathology·Quentin M Anstee, Robert D Goldin
Dec 26, 2006·Chemico-biological Interactions·María José Gómez-LechónJosé-Enrique O'Connor
Mar 21, 2007·Obesity·Molly HarringtonCharlotte M Boney
Jun 15, 2007·Biochimica Et Biophysica Acta·Katherine A Burns, John P Vanden Heuvel
Jul 31, 2007·Biochimica Et Biophysica Acta·Christina VockFrank Döring
Jan 8, 2008·World Journal of Gastroenterology : WJG·Eric R KallwitzScott J Cotler
Oct 1, 2008·Progress in Lipid Research·Giovanni MussoMaurizio Cassader
Apr 11, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P TessariA Tiengo
May 7, 2009·Cell Metabolism·Bei B ZhangCai Li
Oct 23, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G MussoM Cassader
Oct 27, 2009·FEBS Letters·Ting WangHitoshi Yamashita
Nov 17, 2009·Free Radical Biology & Medicine·Sudhir ChowdhryJohn D Hayes
Jan 27, 2010·Digestive Diseases and Sciences·Jeffrey R Lewis, Smruti R Mohanty
Jul 3, 2010·Journal of Gastroenterology and Hepatology·Elango KathirvelTimothy R Morgan
Aug 11, 2010·World Journal of Gastroenterology : WJG·Yoon Mee YangSang Geon Kim
Jan 5, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ting WangKazuyuki Suzuki

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Citations

Nov 23, 2013·Free Radical Biology & Medicine·Takumi SatohStuart A Lipton
Dec 10, 2013·Journal of Gastroenterology·Carmen Berasain, Matías A Avila
Aug 1, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ting Wang, Yasuhiro Takikawa
Feb 5, 2016·Canadian Journal of Physiology and Pharmacology·Xinyao TianZhaoqian Liu
Feb 3, 2015·Phytochemistry·Simona BirtićMarc Roller
Jul 31, 2013·Free Radical Biology & Medicine·Takumi SatohStuart A Lipton
Mar 21, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Madina NaimiEvangelia Tsiani
May 15, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Faezeh Vahdati HassaniHossein Hosseinzadeh
Oct 31, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Xiang Lin, Disheng Wang
Oct 4, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sana BahriVadim Shlyonsky
Nov 9, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kaihan LouZhiyong He
Oct 8, 2016·Clinical and Experimental Pharmacology & Physiology·Madina NaimiEvangelia Tsiani
Jan 26, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Qi GuoPengyuan Zheng
Sep 16, 2020·Molecular Biology Reports·Bibi Marjan RazaviHossein Hosseinzadeh
Jul 17, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jingqi ZhaoJie Zhang

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