Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat

Neuroscience Letters
Xiao-hua WuZhong Chen

Abstract

Carnosine (beta-alanyl-l-histidine) has been characterized as a putative neurotransmitter. However, so far, understanding of the role of carnosine in the brain is very limited. The objective of this study was to examine the effects of carnosine on the development of pentylenetetrazol (PTZ) kindling seizures and protection against the PTZ kindled seizures in rats. Chemical kindling was elicited by repeated intraperitoneal injection of PTZ (35 mg/kg) once every 48 h until the occurrence of Stage 4-5 seizures, and the seizure activity of kindling was recorded for 30 min. In an acute PTZ challenge study, 60 mg/kg PTZ was used to induce kindled seizure. Injection of carnosine (200, 500 mg/kg, i.p.) significantly decreased seizure stage, and prolonged the latencies for myoclonic jerks, in a dose- and time-dependent manner. In the seizure development process, 500 mg/kg carnosine also significantly delayed the onset of PTZ kindled seizures. In addition, carnosine significantly reversed decreased histamine levels induced by PTZ kindled seizure in the hippocampus. These results indicate that carnosine can protect against PTZ-induced seizures in both the development of kindling and the challenge process in rats. The results suggest that c...Continue Reading

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Citations

Nov 21, 2007·Cellular and Molecular Neurobiology·Qiuli FuZhong Chen
Jun 26, 2007·Neuroscience Letters·Ying-xia GongZhong Chen
Mar 1, 2012·European Journal of Pharmacology·Masahiro OhsawaJunzo Kamei
Nov 30, 2011·Journal of Pharmacological Sciences·Bun TsoiHiroshi Kurihara
Oct 14, 2017·Journal of Child and Adolescent Psychopharmacology·Reihaneh Hajizadeh-ZakerShahin Akhondzadeh
Jul 9, 2009·Journal of Zhejiang University. Science. B·Zhou-Yan FengJing Wang
Jul 20, 2019·Experimental Brain Research·Serdar AlpdoganToni Schneider
Sep 1, 2020·Archives of Gerontology and Geriatrics·Soumyabrata Banerjee, Mrinal K Poddar
Apr 27, 2021·Frontiers in Neuroscience·Maria Florencia AcutainMaria Verónica Baez
Mar 24, 2020·Chemical Research in Toxicology·Klaudia ChmielewskaMaja Przybyłowska
Oct 13, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiaoqiong MaJun Yang
Oct 3, 2021·British Journal of Pharmacology·Lin YangZhong Chen

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