Carnosine and Histidine Supplementation Blunt Lead-Induced Reproductive Toxicity through Antioxidative and Mitochondria-Dependent Mechanisms

Biological Trace Element Research
Mohammad Mehdi OmmatiBabak Shirazi Yeganeh

Abstract

Lead (Pb)-induced reproductive toxicity is a well-characterized adverse effect associated with this heavy metal. It has been found that Pb exposure is associated with altered spermatogenesis, increased testicular degeneration, and pathological sperm alterations. On the other hand, it has been reported that Pb-induced reproductive toxicity is associated with increased reactive oxygen species (ROS) formation and diminished antioxidant capacity in the reproductive system. Hence, administration of antioxidants as protective agents might be of value against Pb-induced reproductive toxicity. This study was designed to investigate whether carnosine (CAR) and histidine (HIS) supplementation would mitigate the Pb-induced reproductive toxicity in male rats. Animals received Pb (20 mg/kg/day, oral, 14 consecutive days) alone or in combination with CAR (250 and 500 mg/kg/day, oral, 14 consecutive days) or HIS (250 and 500 mg/kg/day, oral, 14 consecutive days). Pb toxicity was evident in the reproductive system by a significant increase in tissue markers of oxidative stress along with severe histopathological changes, seminal tubule damage, tubular desquamation, low spermatogenesis index, poor sperm parameters, and impaired sperm mitochondr...Continue Reading

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Citations

Aug 9, 2020·The American Journal of Clinical Nutrition·Mary E GhellerAnna E Thalacker-Mercer
Jul 28, 2020·Biological Trace Element Research·Mohammad Mehdi OmmatiReza Heidari
Aug 16, 2019·International Journal of Environmental Research and Public Health·Al Omar S YousefRami B Kassab
Oct 26, 2018·Biological Trace Element Research·Mohammad Mehdi OmmatiHossein Niknahad
Jun 11, 2020·Nutrition & Metabolism·Gulisudumu MaitiabolaXinying Wang
Oct 2, 2020·The Journal of Nutrition·Anna E Thalacker-Mercer, Mary E Gheller
Jan 5, 2021·Frontiers in Veterinary Science·Omid FarshadMohammad Mehdi Ommati
Oct 28, 2020·Biological Trace Element Research·Zahra KhodabandehNegar Azarpira
Nov 26, 2020·Journal of Experimental Pharmacology·Omid FarshadAkram Jamshidzadeh
May 29, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Parisa DolatiIman Jamhiri

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Methods Mentioned

BETA
light microscopy
Assay
MDA

Software Mentioned

SPSS

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