Carnosine-graphene oxide conjugates decorated with hydroxyapatite as promising nanocarrier for ICG loading with enhanced antibacterial effects in photodynamic therapy against Streptococcus mutans

Journal of Photochemistry and Photobiology. B, Biology
Elham GholibeglooMehdi Khoobi

Abstract

Antimicrobial photodynamic therapy (aPDT) has been emerged as a noninvasive strategy to remove bacterial contaminants such as S. mutans from the tooth surface. Photosensitizer (PS), like indocyanine green (ICG), plays a key role in this technique which mainly suffers from the poor stability and concentration-dependent aggregation. An appropriate nanocarrier (NC) with enhanced antibacterial effects could overcome these limitations and improve the efficiency of ICG as a PS. In this study, various ICG-loaded NCs including graphene oxide (GO), GO-carnosine (Car) and GO-Car/Hydroxyapatite (HAp) were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Filed Emission Scanning Electron Microscopy (FE-SEM), Energy Dispersive Spectroscopy (EDS), Zeta Potential and Ultraviolet-Visible spectrometry (UV-Vis). The colony forming unit and crystal violet assays were performed to evaluate the antimicrobial and anti-biofilm properties of PSs against S. mutans. The quantitative real-time PCR approach was also applied to determine the expression ratio of the gtfB gene in S. mutans. The zeta potential analysis and UV-Vis spectrometry indicated successful loading of ICG onto/into NCs. GO-Car/HAp...Continue Reading

Citations

Jul 28, 2018·PloS One·Steven DenyerAnkit I Mehta
Aug 15, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Mahdieh AlipourVahideh Raeisdasteh Hokmabad
Jul 28, 2020·Photobiomodulation, Photomedicine, and Laser Surgery·Abdulrahman A BalhaddadMary Anne S Melo
Jul 26, 2019·International Journal of Molecular Sciences·Analú Barros de OliveiraCarla Raquel Fontana
Feb 3, 2021·Colloids and Surfaces. B, Biointerfaces·Guihua CaoJianbin Guo
Dec 15, 2020·Journal of Environmental Health Science & Engineering·Maryam KeykhaeeMahmood Alimohammadi
Dec 6, 2019·ACS Applied Materials & Interfaces·Behzad ChangalvaieKeith P Johnston
Oct 1, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Lucas N de OliveiraLinda V E Caldas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.