Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis

Frontiers in Immunology
Xing LiYuan Zhang

Abstract

Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine have been used for thousands of years. Carnosol as a bioactive diterpene compound originated from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs extensively applied in traditional medicine for the treatment of multiple autoimmune diseases (1). In this study, we investigated the therapeutic effects and molecule mechanism of carnosol in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Carnosol treatment significantly alleviated clinical development in the myelin oligodendrocyte glycoprotein (MOG35-55) peptide-induced EAE model, markedly decreased inflammatory cell infiltration into the central nervous system and reduced demyelination. Further, carnosol inhibited Th17 cell differentiation and signal transducer and activator of transcription 3 phosphorylation, and blocked transcription factor NF-κB nuclear translocation. In the passive-EAE model, carnosol treatment also significantly prevented Th17 cell pathogenicity. Moreover, carnosol exerted its therapeutic effects in the chronic stage of EAE, and, remarkably, switched the phenotypes of infiltrated macrophage/microglia. Taken toget...Continue Reading

References

May 26, 1998·Journal of Neuropathology and Experimental Neurology·D GvericJ Newcombe
Aug 18, 2005·The Journal of Biological Chemistry·Carl Y SasakiDan L Longo
May 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhi ChenJohn J O'Shea
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anubhav N MathurMark H Kaplan
Nov 21, 2007·Annals of the Rheumatic Diseases·Mohamed Oukka
May 30, 2008·Current Opinion in Immunology·Tyler J Curiel
Sep 2, 2008·Brain : a Journal of Neurology·Stefano PluchinoGianvito Martino
Oct 3, 2009·Science·Ashutosh ChaudhryAlexander Y Rudensky
Apr 7, 2012·Clinical & Developmental Immunology·Alexander VisekrunaUlrich Steinhoff
Jun 16, 2012·Clinical Reviews in Allergy & Immunology·Cindy L H YangAllan S Y Lau
Jul 23, 2013·Nature Neuroscience·Veronique E MironCharles Ffrench-Constant
Aug 15, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Roberta ForestiRoberto Motterlini
Jul 17, 2014·Journal of Immunotoxicology·Maryam RahnamaBamdad Riahi-Zanjani
Dec 22, 2014·The Journal of Allergy and Clinical Immunology·Francesco AnnunziatoSergio Romagnani
Dec 20, 2015·Immunity·Dhavalkumar D Patel, Vijay K Kuchroo
Jan 23, 2016·Journal of Receptor and Signal Transduction Research·Zhi-Hui WangYu-Bo Hou
Apr 14, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joseph SchwagerDaniel Raederstorff
May 21, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xing LiGuang-Xian Zhang
Oct 22, 2016·Acta Neuropathologica·Hans Lassmann, Monika Bradl
Dec 31, 2016·Cardiovascular & Hematological Disorders Drug Targets·Saeed SamarghandianTahere Farkhondeh
Jan 21, 2017·Nature Reviews. Neurology·Bernhard Hemmer, Mark Mühlau
Apr 26, 2017·The Cochrane Database of Systematic Reviews·Graziella FilippiniGeorgia Salanti
Sep 9, 2017·Journal of the Science of Food and Agriculture·Francesca OlivieroPaolo Spinella
Oct 1, 2017·Brain, Behavior, and Immunity·Li-Mei WangYu-Ming Xu
Nov 7, 2017·Nature Reviews. Neurology·Lidia M YshiiRoland S Liblau
Dec 26, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuan ZhangXing Li

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Citations

Jun 4, 2019·International Journal of Rheumatic Diseases·Rupesh Kumar GautamKamal Dua
Jul 8, 2020·Biomolecules & Therapeutics·Jung-Eun Lee, Dong-Soon Im
Aug 4, 2019·Neurochemistry International·Leila MohtashamiBehjat Javadi
May 6, 2021·Journal of Cachexia, Sarcopenia and Muscle·Shanshan LuXiongwen Zhang

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Methods Mentioned

BETA
ELISA
PCR
light microscopy
flow cytometry
nuclear
nuclear translocation

Software Mentioned

GraphPad Prism
FlowJo
Pro
Image
Pro Plus

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