PMID: 8600974Mar 15, 1996Paper

Carotenoid biosynthesis in wild type and mutant strains of Mucor circinelloides

Biochimica Et Biophysica Acta
Paul D FraserP M Bramley

Abstract

Carotenoid biosynthesis in wild type Mucor circinelloides has been investigated and the biochemical characterisation of the MS1 and MS9 mutant strains, impaired in carotenoid formation, carried out. In liquid cultures, all strains produced carotenoids (mainly beta-carotene, but also xi-carotene, lycopene and gamma-carotene) at the onset of stationary phase of growth. Carotenogenesis was light dependent. In liquid cultures carotenoid formation in wild type was affected by diphenylamine, which prevented desaturation, nicotine, resulting in reduced carotenoid levels, but CPTA caused an increase in the total carotenoid content but a reduced beta-carotene level, with the accumulation of lycopene and gamma-carotene. The mutant strains MS1 and MS9 contained only 5.0 and 11.5% of wild type carotenoid levels, respectively. Cell extracts of light-grown mycelia, incubated with 3(R)-[2-14C] mevalonic acid, produced beta-carotene, but incorporations into carotenoids were substantially reduced in the cell extracts of MS1 and MS9. Analysis of prenyl diphosphate intermediates indicated that, compared to wild type, geranylgeranyl diphosphate accumulated in MS1. MS9 extracts produced a larger amount of prenyl phosphates and a more even distribut...Continue Reading

References

May 1, 1954·Archives of Biochemistry and Biophysics·M ZALOKAR

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Citations

Dec 12, 2012·Applied Microbiology and Biotechnology·Tamás PappCsaba Vágvölgyi
Jan 29, 2000·European Journal of Biochemistry·E NavarroS Torres-Martínez
Jul 9, 2004·Applied and Environmental Microbiology·Verena SiewersPaul Tudzynski
Mar 10, 2005·Microbiology and Molecular Biology Reviews : MMBR·Daisuke UmenoFrances H Arnold
Oct 7, 2014·Current Genetics·Javier Avalos, M Carmen Limón
Jul 12, 2002·Acta Microbiologica Et Immunologica Hungarica·Klára AcsCs Vágvölgyi
Aug 1, 1997·Fungal Genetics and Biology : FG & B·A VelayosA P Eslava
Sep 1, 2005·Mycobiology·Bhushan ShresthaJae-Mo Sung
Oct 18, 2002·Journal of Advanced Nursing·Peter Wimpenny
Dec 19, 2018·Applied Microbiology and Biotechnology·Cassamo Ussemane MussagyJorge Fernando Brandão Pereira
Apr 3, 2021·Critical Reviews in Food Science and Nutrition·Cassamo Ussemane MussagyAnna Maria Kot
May 1, 2021·Journal of Fungi·Simona DzurendovaVolha Shapaval

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