PMID: 8583143Nov 1, 1995Paper

Carotenoids and tocopherols in various hepatobiliary conditions

Journal of Hepatology
M A LeoC S Lieber

Abstract

Previous studies revealed hepatic interactions of beta-carotene with alcohol in non-human primates, but bile carotenoids and alpha-tocopherol have not previously been explored in man. To compare the plasma and biliary concentrations of carotenoids, retinoids and tocopherols among controls and patients with biliary and pancreatic diseases, these compounds were measured by high performance liquid chromatography in bile collected during 41 endoscopic retrograde cholangiopancreatographies. In 14 subjects with normal endoscopic retrograde cholangiopancreatography (controls), bile contained beta-carotene, alpha-carotene, lycopene, cryptoxanthin, lutein+zeaxanthin (23.9 +/- 6.6, 3.9 +/- 1.1, 39.9 +/- 21.6, 22.5 +/- 4.6, 217.1 +/- 27.8 nmol/l, respectively) with corresponding plasma values of 399.7 +/- 72.6, 88.5 +/- 18.8, 588.2 +/- 75.0, 145.1 +/- 25.9, 319.3 +/- 33.7 nmol/l. In 13 patients in whom bile duct stones impaired biliary excretion (as reflected by raised serum bilirubin), beta-carotene was significantly decreased in both plasma (199.6 +/- 35.5 nmol/l) and bile (9.4 +/- 2.0 nmol/l), with a similar trend for other carotenoids. The beta-carotene plasma/bile ratio was maintained, as well as a correlation between the two (r = 0....Continue Reading

References

May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A LeoC S Lieber
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Citations

Jun 25, 2002·Molecular Aspects of Medicine·Wilhelm StahlSiân B Astley
Mar 29, 2000·Alimentary Pharmacology & Therapeutics·A FloreaniA D'odorico
Oct 17, 2012·The American Naturalist·Geoffrey E Hill, James D Johnson
Apr 14, 2011·BioFactors·Akihiko Nagao
Jun 5, 2003·Journal of Lipid Research·Shawna L LemkeAndrew J Clifford
May 19, 2010·Journal of Pediatric Gastroenterology and Nutrition·Piotr SochaRoman Lorenc
May 9, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Viviane TyssandierPatrick Borel
Jun 5, 1999·The American Journal of Clinical Nutrition·M A Leo, C S Lieber

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