Carotenoids: Experimental Ionization Energies and Capacity at Inhibiting Lipid Peroxidation in a Chemical Model of Dietary Oxidative Stress

The Journal of Physical Chemistry. B
Pascale GoupyCatherine Caris-Veyrat

Abstract

Carotenoids are important natural pigments and micronutrients contributing to health prevention by several mechanisms, including their electron-donating (antioxidant) activity. In this work, a large series of carotenoids, including 11 carotenes and 14 xanthophylls, have been investigated by wavelength-resolved atmospheric pressure photoionization mass spectrometry (DISCO line of SOLEIL synchrotron), thus allowing the experimental determination of their ionization energy (IE) for the first time. On the other hand, the carotenoids have been also investigated for their ability to inhibit the heme iron-induced peroxidation of linoleic acid in mildly acidic micelles, a simple but relevant chemical model of oxidative stress in the gastric compartment. Thus, the carotenoids can be easily classified from IC50 concentrations deduced from the time dependence of the lipid hydroperoxide concentration. With a selection of two carotenes and three xanthophylls a quantitative analysis is also provided to extract stoichio-kinetic parameters. The influence of the carotenoid structure (number of conjugated carbon-carbon double bonds, presence of terminal six-membered rings, hydroxyl, keto, and/or epoxy groups) on the IE, IC50, and stoichio-kineti...Continue Reading

References

Apr 22, 1996·FEBS Letters·N J MillerC A Rice-Evans
Jan 1, 1996·Chemical Research in Toxicology·D C Liebler, T D McClure
Jul 1, 1997·Free Radical Research·L V JørgensenL H Skibsted
Aug 25, 2004·Archives of Biochemistry and Biophysics·Ali El-AgameyAndrew J Young
Aug 22, 2008·The Journal of Physical Chemistry. a·Ana MartínezMiguel Costas
Oct 22, 2009·Journal of Synchrotron Radiation·Alexandre GiulianiMatthieu Réfrégiers
Sep 11, 2010·Critical Reviews in Food Science and Nutrition·K K Namitha, P S Negi
Jun 21, 2011·Journal of Synchrotron Radiation·Alexandre GiulianiMatthieu Refregiers
Feb 22, 2012·Journal of Agricultural and Food Chemistry·Leif H Skibsted
Jul 30, 2014·The Journal of Physical Chemistry. B·Ana MartínezAntonio J Meléndez-Martínez

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Citations

Jan 30, 2019·Oxidative Medicine and Cellular Longevity·Yunsoo KimOran Kwon
Apr 15, 2020·International Journal of Molecular Sciences·Francesca OppedisanoVincenzo Mollace
Jun 10, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Graziele Freitas de BemAngela Castro Resende
Feb 8, 2020·Journal of Agricultural and Food Chemistry·Thomas HeymannMarcus A Glomb
May 27, 2021·Rapid Communications in Mass Spectrometry : RCM·M Caleb Bagley, David C Muddiman

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