Abstract
1. Patients with insulin-dependent diabetes mellitus are classified among the groups at risk for low vitamin status, and recent studies suggest that some degree of supplementation with antioxidants may be beneficial in helping to prevent certain long-term complications of diabetes mellitus. Our objective was to compare the status of the fat-soluble vitamins and antioxidant-related compounds in patients with well-defined insulin-dependent diabetes mellitus with that of their first-degree relatives, controlling seasonal and analytical variability as factors influencing the interpretation of the data. 2. Fifty-four patients with insulin-dependent diabetes mellitus, 214 non-diabetic, first-degree relatives (controls) and 236 unrelated controls were analysed for retinol, tocopherols (alpha and gamma) and main carotenoids in serum (beta-carotene, alpha-carotene, beta-cryptoxanthin, lutein, zeaxanthin and lycopene) by means of a validated HPLC method. 3. Insulin-dependent diabetes mellitus was associated with lower retinol levels and higher levels of beta-carotene, alpha-carotene and beta-cryptoxanthin than sex-matched, first-degree relatives. alpha-Tocopherol, the alpha-tocopherol/cholesterol ratio, gamma-tocopherol, lutein, zeaxanth...Continue Reading
Citations
Jun 11, 2015·Journal of Clinical Biochemistry and Nutrition·Kimitaka TakitaniHiroshi Tamai
Jan 1, 2014·Journal of Nutritional Science and Vitaminology·Kimitaka TakitaniHiroshi Tamai
Jan 1, 2008·BioFactors·Kimitaka TakitaniHiroshi Tamai
Nov 7, 2012·IUBMB Life·Raghu PullakhandamGeereddy Bhanuprakash Reddy
Oct 22, 2014·The Journal of Obstetrics and Gynaecology Research·Remzi AtilganEkrem Sapmaz
Aug 28, 2004·Annals of Nutrition & Metabolism·F GranadoI Blanco
Nov 8, 2012·Bioscience, Biotechnology, and Biochemistry·Naoki TakaishiMakoto Shimizu
Jul 12, 2003·Eye·M Donaldson, P M Dodson
Feb 20, 2002·Journal of Internal Medicine·J VessbyB Vessby
Jun 17, 2008·The British Journal of Nutrition·Laima BrazionisKerin O'Dea
Jul 6, 2005·The Tohoku Journal of Experimental Medicine·Oguz OzcelikHaluk Kelestimur
Feb 3, 2006·European Journal of Clinical Nutrition·F Granado-LorencioA Simal-Antón
Oct 25, 2007·Pediatric Research·Katharina EspeFlorian J Schweigert
Jun 6, 2014·International Journal of Radiation Biology·Aïda LahbibHafedh Abdelmelek
Nov 28, 2008·Molecular Nutrition & Food Research·Giuseppe MaianiUlrich Schlemmer
Aug 5, 2000·The Journal of Nutrition·J LuT K Basu
Mar 9, 2000·Diabetes/metabolism Research and Reviews·M C PolidoriU Senin
Nov 25, 2020·Journal of Medicinal Food·Yan ZhangGuoxun Chen
Jul 25, 2017·The American Journal of Pathology·Volha V MalechkaJian-Xing Ma